5(S)-<(tert-butyloxycarbonyl)amino>-2-benzyl-2-(carboxy)-6-<4-<<(2,6-dichlorophenyl)methyl>oxy>phenyl>-4-oxohexanoic acid

Base Information

Chemical Name:5(S)-<(tert-butyloxycarbonyl)amino>-2-benzyl-2-(carboxy)-6-<4-<<(2,6-dichlorophenyl)methyl>oxy>phenyl>-4-oxohexanoic acid
CAS No.:161805-83-0
Molecular Formula:C₃₂H₃₃Cl₂NO₈
Molecular Weight:630.522
Hs Code.:

Synonyms:5(S)-<(tert-butyloxycarbonyl)amino>-2-benzyl-2-(carboxy)-6-<4-<<(2,6-dichlorophenyl)methyl>oxy>phenyl>-4-oxohexanoic acid

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Chemical Property of 5(S)-<(tert-butyloxycarbonyl)amino>-2-benzyl-2-(carboxy)-6-<4-<<(2,6-dichlorophenyl)methyl>oxy>phenyl>-4-oxohexanoic acid

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Technology Process of 5(S)-<(tert-butyloxycarbonyl)amino>-2-benzyl-2-(carboxy)-6-<4-<<(2,6-dichlorophenyl)methyl>oxy>phenyl>-4-oxohexanoic acid

There total 4 articles about 5(S)-<(tert-butyloxycarbonyl)amino>-2-benzyl-2-(carboxy)-6-<4-<<(2,6-dichlorophenyl)methyl>oxy>phenyl>-4-oxohexanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 161805-81-8
benzyl 5(S)-<(tert-butyloxycarbonyl)amino>-2-benzyl-2-(benzyloxycarbonyl)-6-<4-<<(2,6-dichlorophenyl)methyl>oxy>phenyl>-4-oxohexanoate

: 161805-83-0
5(S)-<(tert-butyloxycarbonyl)amino>-2-benzyl-2-(carboxy)-6-<4-<<(2,6-dichlorophenyl)methyl>oxy>phenyl>-4-oxohexanoic acid

Guidance literature:: With hydrogen; palladium on activated charcoal; In ethyl acetate; for 0.5h; under 1551.4 Torr; Ambient temperature;
DOI:10.1021/jm00006a021

Reference yield:

: 40298-71-3,201334-88-5,69541-62-4
N-tert-butoxycarbonyl-O-2,6-dichlorobenzyl-L-tyrosine

: 161805-83-0
5(S)-<(tert-butyloxycarbonyl)amino>-2-benzyl-2-(carboxy)-6-<4-<<(2,6-dichlorophenyl)methyl>oxy>phenyl>-4-oxohexanoic acid

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) isobutyl chloroformate, N-methylmorpholine, 3.) HCl

2: 1.) sodium iodide / 1.) THF, RT, 15 min, 2.) THF, 1 h

3: 1.) sodium hydride / 1.) THF, 2.) THF, RT, 5 h

4: 96 percent / hydrogen / 10percent Pd/C / ethyl acetate / 0.5 h / 1551.4 Torr / Ambient temperature

With 4-methyl-morpholine; hydrogenchloride; hydrogen; sodium hydride; sodium iodide; isobutyl chloroformate; palladium on activated charcoal; In ethyl acetate;
DOI:10.1021/jm00006a021

Reference yield:

: 161805-77-2
Boc-Tyr(2,6-di-Cl-Bzl)-CH₂Cl

: 161805-83-0
5(S)-<(tert-butyloxycarbonyl)amino>-2-benzyl-2-(carboxy)-6-<4-<<(2,6-dichlorophenyl)methyl>oxy>phenyl>-4-oxohexanoic acid

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) sodium iodide / 1.) THF, RT, 15 min, 2.) THF, 1 h

2: 1.) sodium hydride / 1.) THF, 2.) THF, RT, 5 h

3: 96 percent / hydrogen / 10percent Pd/C / ethyl acetate / 0.5 h / 1551.4 Torr / Ambient temperature

With hydrogen; sodium hydride; sodium iodide; palladium on activated charcoal; In ethyl acetate;
DOI:10.1021/jm00006a021