(4Z)-2-(N-acetylaminomethyl)-1-methyl-4-(4-hydroxybenzylidene)-4,5-dihydro-1H-imidazol-5-one

Base Information

Chemical Name:(4Z)-2-(N-acetylaminomethyl)-1-methyl-4-(4-hydroxybenzylidene)-4,5-dihydro-1H-imidazol-5-one
CAS No.:1274867-44-5
Molecular Formula:C₁₄H₁₅N₃O₃
Molecular Weight:273.291
Hs Code.:

Synonyms:(4Z)-2-(N-acetylaminomethyl)-1-methyl-4-(4-hydroxybenzylidene)-4,5-dihydro-1H-imidazol-5-one

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (4Z)-2-(N-acetylaminomethyl)-1-methyl-4-(4-hydroxybenzylidene)-4,5-dihydro-1H-imidazol-5-one

Chemical Property:

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Technology Process of (4Z)-2-(N-acetylaminomethyl)-1-methyl-4-(4-hydroxybenzylidene)-4,5-dihydro-1H-imidazol-5-one

There total 9 articles about (4Z)-2-(N-acetylaminomethyl)-1-methyl-4-(4-hydroxybenzylidene)-4,5-dihydro-1H-imidazol-5-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

: 2-(2-acetylaminoacetylamino)-3-(4-hydroxyphenyl)-3-(propionyloxy)propionic acid N-methylamide

: 1274867-44-5
(4Z)-2-(N-acetylaminomethyl)-1-methyl-4-(4-hydroxybenzylidene)-4,5-dihydro-1H-imidazol-5-one

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 110 ℃; for 0.666667h; Inert atmosphere;
DOI:10.1021/jo200150b

Reference yield:

: C₂₁H₂₄N₂O₆

: 1274867-44-5
(4Z)-2-(N-acetylaminomethyl)-1-methyl-4-(4-hydroxybenzylidene)-4,5-dihydro-1H-imidazol-5-one

Guidance literature:: Multi-step reaction with 4 steps

1: water; acetonitrile / 3 h / 40 °C

2: zinc(II) chloride / 4 h / 90 °C

3: palladium 10% on activated carbon; hydrogen; acetic acid / ethanol / 4 h / 20 °C

4: potassium carbonate / N,N-dimethyl-formamide / 0.67 h / 110 °C / Inert atmosphere

With palladium 10% on activated carbon; hydrogen; potassium carbonate; acetic acid; zinc(II) chloride; In ethanol; water; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/jo200150b

Reference yield:

: 2-amino-3-(4-(benzyloxy)phenyl)-3-hydroxypropionic acid methyl ester

: 1274867-44-5
(4Z)-2-(N-acetylaminomethyl)-1-methyl-4-(4-hydroxybenzylidene)-4,5-dihydro-1H-imidazol-5-one

Guidance literature:: Multi-step reaction with 5 steps

1: benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide / tetrahydrofuran; N,N-dimethyl-formamide

2: water; acetonitrile / 3 h / 40 °C

3: zinc(II) chloride / 4 h / 90 °C

4: palladium 10% on activated carbon; hydrogen; acetic acid / ethanol / 4 h / 20 °C

5: potassium carbonate / N,N-dimethyl-formamide / 0.67 h / 110 °C / Inert atmosphere

With palladium 10% on activated carbon; hydrogen; potassium carbonate; benzotriazol-1-ol; acetic acid; N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide; zinc(II) chloride; In tetrahydrofuran; ethanol; water; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/jo200150b