6-[2-chloro-5-((2S,3R,4R,5S,6R)-3,4,5-trihydroxy-6-hydroxymethyl-tetrahydro-pyran-2-yl)-benzyl]-2,2-spirocyclopentyl-chroman-4-one

Base Information

Chemical Name:6-[2-chloro-5-((2S,3R,4R,5S,6R)-3,4,5-trihydroxy-6-hydroxymethyl-tetrahydro-pyran-2-yl)-benzyl]-2,2-spirocyclopentyl-chroman-4-one
CAS No.:1291094-26-2
Molecular Formula:C₂₆H₂₉ClO₇
Molecular Weight:488.965
Hs Code.:

Synonyms:6-[2-chloro-5-((2S,3R,4R,5S,6R)-3,4,5-trihydroxy-6-hydroxymethyl-tetrahydro-pyran-2-yl)-benzyl]-2,2-spirocyclopentyl-chroman-4-one

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Chemical Property of 6-[2-chloro-5-((2S,3R,4R,5S,6R)-3,4,5-trihydroxy-6-hydroxymethyl-tetrahydro-pyran-2-yl)-benzyl]-2,2-spirocyclopentyl-chroman-4-one

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Technology Process of 6-[2-chloro-5-((2S,3R,4R,5S,6R)-3,4,5-trihydroxy-6-hydroxymethyl-tetrahydro-pyran-2-yl)-benzyl]-2,2-spirocyclopentyl-chroman-4-one

There total 3 articles about 6-[2-chloro-5-((2S,3R,4R,5S,6R)-3,4,5-trihydroxy-6-hydroxymethyl-tetrahydro-pyran-2-yl)-benzyl]-2,2-spirocyclopentyl-chroman-4-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1291094-27-3
C₃₄H₃₇ClO₁₁

: 1291094-26-2
6-[2-chloro-5-((2S,3R,4R,5S,6R)-3,4,5-trihydroxy-6-hydroxymethyl-tetrahydro-pyran-2-yl)-benzyl]-2,2-spirocyclopentyl-chroman-4-one

Guidance literature:: With water; lithium hydroxide; In tetrahydrofuran; methanol; at 20 ℃; for 3h;

Reference yield:

: 461432-25-7
(2R,3R,4R,5S,6S)-2-(acetoxymethyl)-6-(4-chloro-3-(4-ethoxybenzyl)phenyl)tetrahydro-2H-pyran-3,4,5-triyl triacetate

: 1291094-26-2
6-[2-chloro-5-((2S,3R,4R,5S,6R)-3,4,5-trihydroxy-6-hydroxymethyl-tetrahydro-pyran-2-yl)-benzyl]-2,2-spirocyclopentyl-chroman-4-one

Guidance literature:: Multi-step reaction with 3 steps

1: aluminum (III) chloride / 1,2-dichloro-ethane / 0 - 50 °C

2: pyrrolidine / 0.07 h / Irradiation with microwave

3: water; lithium hydroxide / tetrahydrofuran; methanol / 3 h / 20 °C

With pyrrolidine; aluminum (III) chloride; water; lithium hydroxide; In tetrahydrofuran; methanol; 1,2-dichloro-ethane;

Reference yield:

: 1291094-21-7
acetic acid (2R,3R,4R,SS,6S)-3,4,5-triacetoxy-6-[3-(3-acetyl-4-hydroxybenzyl)-4-chloro-phenyl]-tetrahydro-pyran-2-ylmethyl ester

: 1291094-26-2
6-[2-chloro-5-((2S,3R,4R,5S,6R)-3,4,5-trihydroxy-6-hydroxymethyl-tetrahydro-pyran-2-yl)-benzyl]-2,2-spirocyclopentyl-chroman-4-one

Guidance literature:: Multi-step reaction with 2 steps

1: pyrrolidine / 0.07 h / Irradiation with microwave

2: water; lithium hydroxide / tetrahydrofuran; methanol / 3 h / 20 °C

With pyrrolidine; water; lithium hydroxide; In tetrahydrofuran; methanol;