N-hydroxy-3-(5-(4-sulfamoylphenyl)-1-(4-(trifluoromethyl)phenyl)-1H-1,2,4-triazol-3-ylthio)propanamide

Base Information

Chemical Name:N-hydroxy-3-(5-(4-sulfamoylphenyl)-1-(4-(trifluoromethyl)phenyl)-1H-1,2,4-triazol-3-ylthio)propanamide
CAS No.:1579938-89-8
Molecular Formula:C₁₈H₁₆F₃N₅O₄S₂
Molecular Weight:487.483
Hs Code.:

Synonyms:N-hydroxy-3-(5-(4-sulfamoylphenyl)-1-(4-(trifluoromethyl)phenyl)-1H-1,2,4-triazol-3-ylthio)propanamide

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Chemical Property of N-hydroxy-3-(5-(4-sulfamoylphenyl)-1-(4-(trifluoromethyl)phenyl)-1H-1,2,4-triazol-3-ylthio)propanamide

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Technology Process of N-hydroxy-3-(5-(4-sulfamoylphenyl)-1-(4-(trifluoromethyl)phenyl)-1H-1,2,4-triazol-3-ylthio)propanamide

There total 6 articles about N-hydroxy-3-(5-(4-sulfamoylphenyl)-1-(4-(trifluoromethyl)phenyl)-1H-1,2,4-triazol-3-ylthio)propanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 26.5%

: 1579938-81-0
C₂₀H₁₉F₃N₄O₄S₂

: 1579938-89-8
N-hydroxy-3-(5-(4-sulfamoylphenyl)-1-(4-(trifluoromethyl)phenyl)-1H-1,2,4-triazol-3-ylthio)propanamide

Guidance literature:: With hydroxylamine hydrochloride; potassium hydroxide; In methanol; at 20 - 40 ℃; for 1.5h; pH=10; Reflux;
DOI:10.1039/c3ob41936c

Reference yield:

: 1579939-07-3
C₁₉H₁₉F₃N₄O₂S₂

: 1579938-89-8
N-hydroxy-3-(5-(4-sulfamoylphenyl)-1-(4-(trifluoromethyl)phenyl)-1H-1,2,4-triazol-3-ylthio)propanamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium carbonate / acetone / 0.5 h / 50 °C

1.2: 3 h / Reflux

2.1: trifluoroacetic acid / 24 h / 0 - 20 °C

3.1: hydroxylamine hydrochloride; potassium hydroxide / methanol / 1.5 h / 20 - 40 °C / pH 10 / Reflux

With hydroxylamine hydrochloride; potassium carbonate; trifluoroacetic acid; potassium hydroxide; In methanol; acetone;
DOI:10.1039/c3ob41936c

Reference yield:

: 1579938-80-9
C₂₄H₂₇F₃N₄O₄S₂

: 1579938-89-8
N-hydroxy-3-(5-(4-sulfamoylphenyl)-1-(4-(trifluoromethyl)phenyl)-1H-1,2,4-triazol-3-ylthio)propanamide

Guidance literature:: Multi-step reaction with 2 steps

1: trifluoroacetic acid / 24 h / 0 - 20 °C

2: hydroxylamine hydrochloride; potassium hydroxide / methanol / 1.5 h / 20 - 40 °C / pH 10 / Reflux

With hydroxylamine hydrochloride; trifluoroacetic acid; potassium hydroxide; In methanol;
DOI:10.1039/c3ob41936c