(4R,5S)-3-(1'-oxo-2'-methylthioethyl)-4-methyl-5-phenyl-2-oxazolidinone

Base Information

Chemical Name:(4R,5S)-3-(1'-oxo-2'-methylthioethyl)-4-methyl-5-phenyl-2-oxazolidinone
CAS No.:116857-38-6
Molecular Formula:C₁₃H₁₅NO₃S
Molecular Weight:265.333
Hs Code.:

Synonyms:(4R,5S)-3-(1'-oxo-2'-methylthioethyl)-4-methyl-5-phenyl-2-oxazolidinone

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (4R,5S)-3-(1'-oxo-2'-methylthioethyl)-4-methyl-5-phenyl-2-oxazolidinone

Chemical Property:

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Technology Process of (4R,5S)-3-(1'-oxo-2'-methylthioethyl)-4-methyl-5-phenyl-2-oxazolidinone

There total 1 articles about (4R,5S)-3-(1'-oxo-2'-methylthioethyl)-4-methyl-5-phenyl-2-oxazolidinone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 77943-39-6
4-methyl-5-phenyloxazolidin-2-one

: 35928-65-5
(methylthio)acetyl chloride

: 116857-38-6
(4R,5S)-3-(1'-oxo-2'-methylthioethyl)-4-methyl-5-phenyl-2-oxazolidinone

Guidance literature:: With n-butyllithium; In tetrahydrofuran; 1.) -78 deg C, 30 min, 2.) r.t., 30 min;
DOI:10.1039/p19960000853

Reference yield: 75.0%

: 120205-56-3
benzyl methyl[(2S,3S)-3-methyl-1-oxopentan-2-yl]carbamate

: 116857-38-6
(4R,5S)-3-(1'-oxo-2'-methylthioethyl)-4-methyl-5-phenyl-2-oxazolidinone

: [(1S,2S,3R)-1-((S)-sec-Butyl)-2-hydroxy-4-((4R,5S)-4-methyl-2-oxo-5-phenyl-oxazolidin-3-yl)-3-methylsulfanyl-4-oxo-butyl]-methyl-carbamic acid benzyl ester

Guidance literature:: With di-n-butylboryl trifluoromethanesulfonate; N-ethyl-N,N-diisopropylamine; In dichloromethane; 1.) -5 deg C, 90 min, 2.) -78 deg C, 17 h; -5 deg C, 90 min;
DOI:10.1039/p19960000853

Reference yield:

: 116857-38-6
(4R,5S)-3-(1'-oxo-2'-methylthioethyl)-4-methyl-5-phenyl-2-oxazolidinone

: 157916-86-4
ethyl 2-<1(R)-hydroxy-2-<((4R,5S)-4-methyl-5-phenyl-2-oxazolidinyl)carbonyl>ethyl>-6-amino-5-methylpyrimidine-4-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) Bu₂BOTf, i-Pr₂NEt, / 1.) CH₂Cl₂, 0 deg C, 1 h, 2.) CH₂Cl₂, 0 deg C, 3 h

2: 93 percent / Bu₃SnH / benzene / 1 h / 80 °C

With di-n-butylboryl trifluoromethanesulfonate; tri-n-butyl-tin hydride; N-ethyl-N,N-diisopropylamine; In benzene;
DOI:10.1021/ja00092a012