1-{5-O-[bis(4-methoxyphenyl)phenylmethyl]-2-deoxy-β-D-erythro-pentofuranosyl}-2H-1,2,3-benzotriazole

Base Information

Chemical Name:1-{5-O-[bis(4-methoxyphenyl)phenylmethyl]-2-deoxy-β-D-erythro-pentofuranosyl}-2H-1,2,3-benzotriazole
CAS No.:857684-47-0
Molecular Formula:C₃₂H₃₁N₃O₅
Molecular Weight:537.615
Hs Code.:

Synonyms:1-{5-O-[bis(4-methoxyphenyl)phenylmethyl]-2-deoxy-β-D-erythro-pentofuranosyl}-2H-1,2,3-benzotriazole

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Chemical Property of 1-{5-O-[bis(4-methoxyphenyl)phenylmethyl]-2-deoxy-β-D-erythro-pentofuranosyl}-2H-1,2,3-benzotriazole

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Technology Process of 1-{5-O-[bis(4-methoxyphenyl)phenylmethyl]-2-deoxy-β-D-erythro-pentofuranosyl}-2H-1,2,3-benzotriazole

There total 4 articles about 1-{5-O-[bis(4-methoxyphenyl)phenylmethyl]-2-deoxy-β-D-erythro-pentofuranosyl}-2H-1,2,3-benzotriazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

: 40615-36-9
4,4'-dimethoxytrityl chloride

: 128553-12-8
2-<2'-Deoxy-β-D-erythro-pentofuranosyl>-2H-benzotriazole

: 857684-47-0
1-{5-O-[bis(4-methoxyphenyl)phenylmethyl]-2-deoxy-β-D-erythro-pentofuranosyl}-2H-1,2,3-benzotriazole

Guidance literature:: With pyridine; dmap; for 5h;
DOI:10.1002/hlca.200590052

Reference yield:

: 95-14-7,27556-51-0
1,2,3-Benzotriazole

: 857684-47-0
1-{5-O-[bis(4-methoxyphenyl)phenylmethyl]-2-deoxy-β-D-erythro-pentofuranosyl}-2H-1,2,3-benzotriazole

Guidance literature:: Multi-step reaction with 3 steps

1.1: NaH / acetonitrile / 0.25 h / 20 °C

1.2: 38 percent / acetonitrile

2.1: 79 percent / NaOMe; MeOH / CH₂Cl₂ / 0.5 h / 20 °C

3.1: N,N-dimethylaminopyridine; pyridine; triethylamine / 18 h / 20 °C

With pyridine; methanol; dmap; sodium methylate; sodium hydride; triethylamine; In dichloromethane; acetonitrile;
DOI:10.1021/ja034099w

Reference yield:

: 128531-09-9
2-<2'-Deoxy-3',5'-di-O-(4-toluoyl)-β-D-erythro-pentofuranosyl>-2H-benzotriazole

: 857684-47-0
1-{5-O-[bis(4-methoxyphenyl)phenylmethyl]-2-deoxy-β-D-erythro-pentofuranosyl}-2H-1,2,3-benzotriazole

Guidance literature:: Multi-step reaction with 2 steps

1: 79 percent / NaOMe; MeOH / CH₂Cl₂ / 0.5 h / 20 °C

2: N,N-dimethylaminopyridine; pyridine; triethylamine / 18 h / 20 °C

With pyridine; methanol; dmap; sodium methylate; triethylamine; In dichloromethane;
DOI:10.1021/ja034099w