Technology Process of {1-[4-(isoquinolin-6-ylamino)-1-methyl-cyclohexyl]-propyl}-carbamic acid benzyl ester
There total 5 articles about {1-[4-(isoquinolin-6-ylamino)-1-methyl-cyclohexyl]-propyl}-carbamic acid benzyl ester which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 5 steps
1: sodium tetrahydroborate / tetrahydrofuran; methanol; diethyl ether / 0 - 20 °C
2: triethylamine / dichloromethane / -78 - 20 °C
3: hydrogenchloride / water; acetone / 16 h / 20 °C
4: ammonium acetate; sodium cyanoborohydride / methanol / 16 h / 20 °C
5: caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl / palladium diacetate / toluene / 100 °C
With
hydrogenchloride; sodium tetrahydroborate; ammonium acetate; sodium cyanoborohydride; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; triethylamine;
palladium diacetate;
In
tetrahydrofuran; methanol; diethyl ether; dichloromethane; water; acetone; toluene;
- Guidance literature:
-
Multi-step reaction with 3 steps
1: hydrogenchloride / water; acetone / 16 h / 20 °C
2: ammonium acetate; sodium cyanoborohydride / methanol / 16 h / 20 °C
3: caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl / palladium diacetate / toluene / 100 °C
With
hydrogenchloride; ammonium acetate; sodium cyanoborohydride; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl;
palladium diacetate;
In
methanol; water; acetone; toluene;
- Guidance literature:
-
Multi-step reaction with 6 steps
1: tetrahydrofuran; diethyl ether / 8 h / Reflux
2: sodium tetrahydroborate / tetrahydrofuran; methanol; diethyl ether / 0 - 20 °C
3: triethylamine / dichloromethane / -78 - 20 °C
4: hydrogenchloride / water; acetone / 16 h / 20 °C
5: ammonium acetate; sodium cyanoborohydride / methanol / 16 h / 20 °C
6: caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl / palladium diacetate / toluene / 100 °C
With
hydrogenchloride; sodium tetrahydroborate; ammonium acetate; sodium cyanoborohydride; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; triethylamine;
palladium diacetate;
In
tetrahydrofuran; methanol; diethyl ether; dichloromethane; water; acetone; toluene;
