3-chloro-5-difluoromethoxytropic acid

Base Information

Chemical Name:3-chloro-5-difluoromethoxytropic acid
CAS No.:433938-67-1
Molecular Formula:C₁₀H₉ClF₂O₄
Molecular Weight:266.629
Hs Code.:

Synonyms:3-chloro-5-difluoromethoxytropic acid

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Chemical Property of 3-chloro-5-difluoromethoxytropic acid

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Technology Process of 3-chloro-5-difluoromethoxytropic acid

There total 1 articles about 3-chloro-5-difluoromethoxytropic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 48.0%

: 433938-66-0
2-formyl-2-(3-chloro-5-difluoromethoxyphenyl)acetic acid methyl ester

: 433938-67-1
3-chloro-5-difluoromethoxytropic acid

Guidance literature:: 2-formyl-2-(3-chloro-5-difluoromethoxyphenyl)acetic acid methyl ester; With sodium tetrahydroborate; In tetrahydrofuran; methanol; at 20 ℃; for 0.5h;

With water; In tetrahydrofuran; methanol;

With sodium hydroxide; water; In methanol; at 20 ℃; for 0.166667h;

Reference yield: 10.4%

: 433938-67-1
3-chloro-5-difluoromethoxytropic acid

: 218597-54-7
H-Aze-Pab(Teoc) hydrochloride

: 631-61-8,92206-38-7
ammonium acetate

: 433937-83-8
Ph(3-Cl)(5-OCHF₂)-(S)CH(CH₂OH)C(O)-Aze-Pab x HOAc

Guidance literature:: 3-chloro-5-difluoromethoxytropic acid; H-Aze-Pab(Teoc) hydrochloride; With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In DMF (N,N-dimethyl-formamide); at 20 ℃; for 1h;

With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 1h;

ammonium acetate; In water; acetonitrile; Chromatography;

Reference yield: 10.4%

: 433938-67-1
3-chloro-5-difluoromethoxytropic acid

: 218597-54-7
H-Aze-Pab(Teoc) hydrochloride

: 76-05-1
trifluoroacetic acid

: Ph(3-Cl)(5-OCHF₂)-(S)CH(CH₂OH)C(O)-Aze-Pab acetate

Guidance literature:: 3-chloro-5-difluoromethoxytropic acid; H-Aze-Pab(Teoc) hydrochloride; With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In DMF (N,N-dimethyl-formamide); at 20 ℃; for 1h;

trifluoroacetic acid; In dichloromethane; at 20 ℃; for 1h;