[4,4-⁽²⁾H₂]-1-(p-tolylsulfonyloxy)-oct-2-yne

Base Information

Chemical Name:[4,4-⁽²⁾H₂]-1-(p-tolylsulfonyloxy)-oct-2-yne
CAS No.:1393604-82-4
Molecular Formula:C₁₅H₂₀O₃S
Molecular Weight:282.372
Hs Code.:

[4,4-<sup>(2)</sup>H<sub>2</sub>]-1-(p-tolylsulfonyloxy)-oct-2-yne

Synonyms:[4,4-⁽²⁾H₂]-1-(p-tolylsulfonyloxy)-oct-2-yne

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Chemical Property of [4,4-⁽²⁾H₂]-1-(p-tolylsulfonyloxy)-oct-2-yne

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Technology Process of [4,4-⁽²⁾H₂]-1-(p-tolylsulfonyloxy)-oct-2-yne

There total 5 articles about [4,4-⁽²⁾H₂]-1-(p-tolylsulfonyloxy)-oct-2-yne which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 1393604-81-3
[4,4-D₂]-oct-2-yn-1-ol

: 98-59-9
p-toluenesulfonyl chloride

: 1393604-82-4
[4,4-⁽²⁾H₂]-1-(p-tolylsulfonyloxy)-oct-2-yne

Guidance literature:: With potassium hydroxide; In diethyl ether; at -50 - 0 ℃; for 2h;
DOI:10.1002/anie.201202080

Reference yield:

: 624-24-8
methyl valerate

: 1393604-82-4
[4,4-⁽²⁾H₂]-1-(p-tolylsulfonyloxy)-oct-2-yne

Guidance literature:: Multi-step reaction with 4 steps

1.1: lithium aluminium deuteride / tetrahydrofuran; diethyl ether / 4 h / 0 - 20 °C

2.1: sulfuric acid; hydrogen bromide / water / 3 h / Reflux

3.1: N,N,N,N,N,N-hexamethylphosphoric triamide; n-butyllithium / tetrahydrofuran; hexane / -30 - 0 °C / Inert atmosphere

3.2: 0 - 20 °C / Inert atmosphere

4.1: potassium hydroxide / diethyl ether / 2 h / -50 - 0 °C

With N,N,N,N,N,N-hexamethylphosphoric triamide; n-butyllithium; lithium aluminium deuteride; sulfuric acid; hydrogen bromide; potassium hydroxide; In tetrahydrofuran; diethyl ether; hexane; water;
DOI:10.1002/anie.201202080

Reference yield:

: 35658-10-7
[1,1-²H₂]-1-pentanol

: 1393604-82-4
[4,4-⁽²⁾H₂]-1-(p-tolylsulfonyloxy)-oct-2-yne

Guidance literature:: Multi-step reaction with 3 steps

1.1: sulfuric acid; hydrogen bromide / water / 3 h / Reflux

2.1: N,N,N,N,N,N-hexamethylphosphoric triamide; n-butyllithium / tetrahydrofuran; hexane / -30 - 0 °C / Inert atmosphere

2.2: 0 - 20 °C / Inert atmosphere

3.1: potassium hydroxide / diethyl ether / 2 h / -50 - 0 °C

With N,N,N,N,N,N-hexamethylphosphoric triamide; n-butyllithium; sulfuric acid; hydrogen bromide; potassium hydroxide; In tetrahydrofuran; diethyl ether; hexane; water;
DOI:10.1002/anie.201202080