(2R,3S,5R)-5-tert-butyldiphenylsilyloxymethyl-2-(2-methoxycarbonylvinyl)-2,3-methano-1-tert-butyloxycarbonylpyrrolidine

Base Information

Chemical Name:(2R,3S,5R)-5-tert-butyldiphenylsilyloxymethyl-2-(2-methoxycarbonylvinyl)-2,3-methano-1-tert-butyloxycarbonylpyrrolidine
CAS No.:433715-83-4
Molecular Formula:C₃₁H₄₁NO₅Si
Molecular Weight:535.756
Hs Code.:

Synonyms:(2R,3S,5R)-5-tert-butyldiphenylsilyloxymethyl-2-(2-methoxycarbonylvinyl)-2,3-methano-1-tert-butyloxycarbonylpyrrolidine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2R,3S,5R)-5-tert-butyldiphenylsilyloxymethyl-2-(2-methoxycarbonylvinyl)-2,3-methano-1-tert-butyloxycarbonylpyrrolidine

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Technology Process of (2R,3S,5R)-5-tert-butyldiphenylsilyloxymethyl-2-(2-methoxycarbonylvinyl)-2,3-methano-1-tert-butyloxycarbonylpyrrolidine

There total 3 articles about (2R,3S,5R)-5-tert-butyldiphenylsilyloxymethyl-2-(2-methoxycarbonylvinyl)-2,3-methano-1-tert-butyloxycarbonylpyrrolidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 433715-82-3
(2R,3S,5R)-5-tert-butyldiphenylsilyloxymethyl-2-propenyl-2,3-methano-1-tert-butyloxycarbonylpyrrolidine

: 433715-83-4
(2R,3S,5R)-5-tert-butyldiphenylsilyloxymethyl-2-(2-methoxycarbonylvinyl)-2,3-methano-1-tert-butyloxycarbonylpyrrolidine

Guidance literature:: Multi-step reaction with 2 steps

1.1: O₃ / CH₂Cl₂ / 0.17 h / -78 °C

1.2: 85 percent / Me₂S / CH₂Cl₂ / -78 - 20 °C

2.1: benzene / 30 h / Heating

With ozone; In dichloromethane; benzene;
DOI:10.1021/jo0111715

Reference yield:

: (3R,5R)-5-tert-butyldiphenylsilyloxymethyl-3-trimethylstannylmethyl-1-tert-butyloxycarbonylpyrrolidin-2-one

: 433715-83-4
(2R,3S,5R)-5-tert-butyldiphenylsilyloxymethyl-2-(2-methoxycarbonylvinyl)-2,3-methano-1-tert-butyloxycarbonylpyrrolidine

Guidance literature:: Multi-step reaction with 3 steps

1.1: tetrahydrofuran; diethyl ether / 1.5 h / -78 °C

1.2: 30 percent / TFA / CH₂Cl₂ / 0.17 h / 0 °C

2.1: O₃ / CH₂Cl₂ / 0.17 h / -78 °C

2.2: 85 percent / Me₂S / CH₂Cl₂ / -78 - 20 °C

3.1: benzene / 30 h / Heating

With ozone; In tetrahydrofuran; diethyl ether; dichloromethane; benzene;
DOI:10.1021/jo0111715