methyl (E)-4-<2-(trifluoromethyl)-2-(4,4-dimethylthiochroman-6-yl)ethenyl>benzoate

Base Information

• Chemical Name: methyl (E)-4-<2-(trifluoromethyl)-2-(4,4-dimethylthiochroman-6-yl)ethenyl>benzoate
• CAS No.: 132102-24-0
• Molecular Formula: C₂₂H₂₁F₃O₂S
• Molecular Weight: 406.469
• Mol file: 132102-24-0.mol

Synonyms:methyl (E)-4-<2-(trifluoromethyl)-2-(4,4-dimethylthiochroman-6-yl)ethenyl>benzoate

Chemical Property of methyl (E)-4-<2-(trifluoromethyl)-2-(4,4-dimethylthiochroman-6-yl)ethenyl>benzoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl (E)-4-<2-(trifluoromethyl)-2-(4,4-dimethylthiochroman-6-yl)ethenyl>benzoate

There total 2 articles about methyl (E)-4-<2-(trifluoromethyl)-2-(4,4-dimethylthiochroman-6-yl)ethenyl>benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.2%

dimethyl (4-carbomethoxybenzyl)phosphonate (78022-19-2) + 4,4-dimethylthiochroman-6-yl trifluoromethyl ketone (132102-32-0) → methyl (E)-4-<2-(trifluoromethyl)-2-(4,4-dimethylthiochroman-6-yl)ethenyl>benzoate (132102-24-0)

Guidance literature:

With 15-crown-5; sodium hydride; In tetrahydrofuran; for 24h; Ambient temperature;

DOI:10.1021/jm00105a065

Reference yield:

4,4-dimethyl-3,4-dihydro-2H-1-benzothiopyran (66165-06-8) → methyl (E)-4-<2-(trifluoromethyl)-2-(4,4-dimethylthiochroman-6-yl)ethenyl>benzoate (132102-24-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 31.3 percent / AlCl₃ / CS₂ / 2 h

2: 61.2 percent / NaH, 15-crown-5 ether / tetrahydrofuran / 24 h / Ambient temperature

With aluminium trichloride; 15-crown-5; sodium hydride; In tetrahydrofuran; carbon disulfide;

DOI:10.1021/jm00105a065

Reference yield: 81.0%

methyl (E)-4-<2-(trifluoromethyl)-2-(4,4-dimethylthiochroman-6-yl)ethenyl>benzoate (132102-24-0) → (E)-4-<2-(trifluoromethyl)-2-(4,4-dimethylthiochroman-6-yl)ethenyl>benzoic acid (132102-25-1)

Guidance literature:

With potassium hydroxide; In ethanol; water; for 1h; Heating;

DOI:10.1021/jm00105a065

upstream raw materials:

dimethyl (4-carbomethoxybenzyl)phosphonate

4,4-dimethylthiochroman-6-yl trifluoromethyl ketone

4,4-dimethyl-3,4-dihydro-2H-1-benzothiopyran

Downstream raw materials:

(E)-4-<2-(trifluoromethyl)-2-(4,4-dimethylthiochroman-6-yl)ethenyl>benzoic acid