3-[2-amino-5-(4-methylphenyl)-7-phenyl-3H-[1,2,4]triazolo[1,5-a]pyrimidin-8-ium-3-yl]propanoate

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Chemical Name:3-[2-amino-5-(4-methylphenyl)-7-phenyl-3H-[1,2,4]triazolo[1,5-a]pyrimidin-8-ium-3-yl]propanoate
CAS No.:1534330-50-1
Molecular Formula:C₂₁H₁₉N₅O₂
Molecular Weight:373.414
Hs Code.:

Synonyms:3-[2-amino-5-(4-methylphenyl)-7-phenyl-3H-[1,2,4]triazolo[1,5-a]pyrimidin-8-ium-3-yl]propanoate

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Chemical Property of 3-[2-amino-5-(4-methylphenyl)-7-phenyl-3H-[1,2,4]triazolo[1,5-a]pyrimidin-8-ium-3-yl]propanoate

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Technology Process of 3-[2-amino-5-(4-methylphenyl)-7-phenyl-3H-[1,2,4]triazolo[1,5-a]pyrimidin-8-ium-3-yl]propanoate

There total 5 articles about 3-[2-amino-5-(4-methylphenyl)-7-phenyl-3H-[1,2,4]triazolo[1,5-a]pyrimidin-8-ium-3-yl]propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.0%

: 1534330-43-2
2-(4-methylphenyl)-8-oxo-4-phenyl-1,2,3,4,9,10-hexahydro-8H-[1,2,4]triazolo[1,5-a:4,3-a′]dipyrimidin-5-ium-7-ide

: 1534330-50-1
3-[2-amino-5-(4-methylphenyl)-7-phenyl-3H-[1,2,4]triazolo[1,5-a]pyrimidin-8-ium-3-yl]propanoate

Guidance literature:: With potassium hydroxide; In ethanol; for 2h; Reflux;
DOI:10.1016/j.tet.2013.11.090

Reference yield:

: C₂₁H₂₀ClN₅O

: 1534330-50-1
3-[2-amino-5-(4-methylphenyl)-7-phenyl-3H-[1,2,4]triazolo[1,5-a]pyrimidin-8-ium-3-yl]propanoate

Guidance literature:: Multi-step reaction with 3 steps

1.1: N,N-dimethyl-formamide; acetonitrile / 0 - 90 °C

2.1: iodine / ethanol / 0.33 h / Reflux

2.2: 0.5 h

3.1: potassium hydroxide / ethanol / 2 h / Reflux

With iodine; potassium hydroxide; In ethanol; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1016/j.tet.2013.11.090

Reference yield:

: 134834-76-7
7-Phenyl-5-p-tolyl-4,7-dihydro-[1,2,4]triazolo[1,5-a]pyrimidin-2-ylamine

: 1534330-50-1
3-[2-amino-5-(4-methylphenyl)-7-phenyl-3H-[1,2,4]triazolo[1,5-a]pyrimidin-8-ium-3-yl]propanoate

Guidance literature:: Multi-step reaction with 4 steps

1.1: pyridine / N,N-dimethyl-formamide; acetonitrile / 0.25 h / 0 - 5 °C

2.1: N,N-dimethyl-formamide; acetonitrile / 0 - 90 °C

3.1: iodine / ethanol / 0.33 h / Reflux

3.2: 0.5 h

4.1: potassium hydroxide / ethanol / 2 h / Reflux

With pyridine; iodine; potassium hydroxide; In ethanol; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1016/j.tet.2013.11.090