methyl 3-(3-mercaptopyridin-2-yl)-3-oxo-2-(2-trifluoromethylphenyl)propionate

Base Information

Chemical Name:methyl 3-(3-mercaptopyridin-2-yl)-3-oxo-2-(2-trifluoromethylphenyl)propionate
CAS No.:1231756-37-8
Molecular Formula:C₁₆H₁₂F₃NO₃S
Molecular Weight:355.337
Hs Code.:

Synonyms:methyl 3-(3-mercaptopyridin-2-yl)-3-oxo-2-(2-trifluoromethylphenyl)propionate

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Chemical Property of methyl 3-(3-mercaptopyridin-2-yl)-3-oxo-2-(2-trifluoromethylphenyl)propionate

Chemical Property:

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Technology Process of methyl 3-(3-mercaptopyridin-2-yl)-3-oxo-2-(2-trifluoromethylphenyl)propionate

There total 5 articles about methyl 3-(3-mercaptopyridin-2-yl)-3-oxo-2-(2-trifluoromethylphenyl)propionate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1309878-86-1
methyl 3-[3-(4-methoxybenzylsulfanyl)pyridin-2-yl]-3-oxo-2-(2-trifluoromethylphenyl)propionate

: 1231756-37-8
methyl 3-(3-mercaptopyridin-2-yl)-3-oxo-2-(2-trifluoromethylphenyl)propionate

Guidance literature:: With trifluorormethanesulfonic acid; trifluoroacetic acid; In dichloromethane; at 0 ℃; for 0.333333h;

Reference yield:

: 54112-52-6
3-(4-methoxy-benzylsulfanyl)-pyridine-2-carboxylic acid

: 1231756-37-8
methyl 3-(3-mercaptopyridin-2-yl)-3-oxo-2-(2-trifluoromethylphenyl)propionate

Guidance literature:: Multi-step reaction with 2 steps

1.1: 1,1'-carbonyldiimidazole / N,N-dimethyl-formamide / 1 h / 20 °C

1.2: 2 h / 20 °C

2.1: trifluoroacetic acid; trifluorormethanesulfonic acid / dichloromethane / 0.33 h / 0 °C

With trifluorormethanesulfonic acid; 1,1'-carbonyldiimidazole; trifluoroacetic acid; In dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 53636-56-9
methyl 3-bromopicolinate

: 1231756-37-8
methyl 3-(3-mercaptopyridin-2-yl)-3-oxo-2-(2-trifluoromethylphenyl)propionate

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydride / dimethyl sulfoxide / 2 h / 0 °C / Inert atmosphere; Reflux

1.2: 90 °C

2.1: water; lithium hydroxide / methanol / 4 h / 20 °C

2.2: pH 5 - 6

3.1: 1,1'-carbonyldiimidazole / N,N-dimethyl-formamide / 1 h / 20 °C

3.2: 2 h / 20 °C

4.1: trifluoroacetic acid; trifluorormethanesulfonic acid / dichloromethane / 0.33 h / 0 °C

With trifluorormethanesulfonic acid; water; sodium hydride; 1,1'-carbonyldiimidazole; trifluoroacetic acid; lithium hydroxide; In methanol; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide;