N-(9-{(2R,4S,5R)-5-[(2R,3S,5R)-2-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(4-hydroxy-5-methyl-2-oxo-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yloxymethoxymethyl]-4-hydroxy-tetrahydro-furan-2-yl}-6-oxo-6,9-dihydro-1H-purin-2-yl)-isobutyramide

Base Information

Chemical Name:N-(9-{(2R,4S,5R)-5-[(2R,3S,5R)-2-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(4-hydroxy-5-methyl-2-oxo-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yloxymethoxymethyl]-4-hydroxy-tetrahydro-furan-2-yl}-6-oxo-6,9-dihydro-1H-purin-2-yl)-isobutyramide
CAS No.:215248-60-5
Molecular Formula:C₄₆H₅₁N₇O₁₂
Molecular Weight:893.951
Hs Code.:

N-(9-{(2R,4S,5R)-5-[(2R,3S,5R)-2-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(4-hydroxy-5-methyl-2-oxo-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yloxymethoxymethyl]-4-hydroxy-tetrahydro-furan-2-yl}-6-oxo-6,9-dihydro-1H-purin-2-yl)-isobutyramide

Synonyms:N-(9-{(2R,4S,5R)-5-[(2R,3S,5R)-2-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(4-hydroxy-5-methyl-2-oxo-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yloxymethoxymethyl]-4-hydroxy-tetrahydro-furan-2-yl}-6-oxo-6,9-dihydro-1H-purin-2-yl)-isobutyramide

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Chemical Property of N-(9-{(2R,4S,5R)-5-[(2R,3S,5R)-2-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(4-hydroxy-5-methyl-2-oxo-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yloxymethoxymethyl]-4-hydroxy-tetrahydro-furan-2-yl}-6-oxo-6,9-dihydro-1H-purin-2-yl)-isobutyramide

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Technology Process of N-(9-{(2R,4S,5R)-5-[(2R,3S,5R)-2-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(4-hydroxy-5-methyl-2-oxo-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yloxymethoxymethyl]-4-hydroxy-tetrahydro-furan-2-yl}-6-oxo-6,9-dihydro-1H-purin-2-yl)-isobutyramide

There total 4 articles about N-(9-{(2R,4S,5R)-5-[(2R,3S,5R)-2-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(4-hydroxy-5-methyl-2-oxo-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yloxymethoxymethyl]-4-hydroxy-tetrahydro-furan-2-yl}-6-oxo-6,9-dihydro-1H-purin-2-yl)-isobutyramide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: Benzoic acid (2R,3S,5R)-5-(4-hydroxy-5-methyl-2-oxo-2H-pyrimidin-1-yl)-3-methylsulfanylmethoxy-tetrahydro-furan-2-ylmethyl ester

: 215248-60-5
N-(9-{(2R,4S,5R)-5-[(2R,3S,5R)-2-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(4-hydroxy-5-methyl-2-oxo-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yloxymethoxymethyl]-4-hydroxy-tetrahydro-furan-2-yl}-6-oxo-6,9-dihydro-1H-purin-2-yl)-isobutyramide

Guidance literature:: Multi-step reaction with 4 steps

1: 67 percent / N-iodosuccinimide / CH₂Cl₂; diethyl ether / 0.5 h / Ambient temperature

2: trimethylsilyl trifluoromethanesulfonate / CH₂Cl₂ / 0.5 h / Ambient temperature

3: aq. KOH / methanol; dioxane / 0.5 h / 0 °C

4: pyridine / Ambient temperature

With pyridine; potassium hydroxide; N-iodo-succinimide; trimethylsilyl trifluoromethanesulfonate; In 1,4-dioxane; methanol; diethyl ether; dichloromethane;
DOI:10.1021/jm970766i

Reference yield:

: 215248-54-7
Benzoic acid (2R,3S,5R)-3-(diphenyl-phosphinoyloxymethoxy)-5-(4-hydroxy-5-methyl-2-oxo-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl ester

: 215248-60-5
N-(9-{(2R,4S,5R)-5-[(2R,3S,5R)-2-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(4-hydroxy-5-methyl-2-oxo-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yloxymethoxymethyl]-4-hydroxy-tetrahydro-furan-2-yl}-6-oxo-6,9-dihydro-1H-purin-2-yl)-isobutyramide

Guidance literature:: Multi-step reaction with 3 steps

1: trimethylsilyl trifluoromethanesulfonate / CH₂Cl₂ / 0.5 h / Ambient temperature

2: aq. KOH / methanol; dioxane / 0.5 h / 0 °C

3: pyridine / Ambient temperature

With pyridine; potassium hydroxide; trimethylsilyl trifluoromethanesulfonate; In 1,4-dioxane; methanol; dichloromethane;
DOI:10.1021/jm970766i

Reference yield:

: C₃₉H₄₁N₇O₁₂

: 215248-60-5
N-(9-{(2R,4S,5R)-5-[(2R,3S,5R)-2-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(4-hydroxy-5-methyl-2-oxo-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yloxymethoxymethyl]-4-hydroxy-tetrahydro-furan-2-yl}-6-oxo-6,9-dihydro-1H-purin-2-yl)-isobutyramide

Guidance literature:: Multi-step reaction with 2 steps

1: aq. KOH / methanol; dioxane / 0.5 h / 0 °C

2: pyridine / Ambient temperature

With pyridine; potassium hydroxide; In 1,4-dioxane; methanol;
DOI:10.1021/jm970766i