3-methyl-1-(2-(4-methylpiperazin-1-yl)-2-oxoethyl)-5-phenyl-1H-benzo[f][1,3,5]triazepine-2,4(3H,5H)-dione

Base Information

Chemical Name:3-methyl-1-(2-(4-methylpiperazin-1-yl)-2-oxoethyl)-5-phenyl-1H-benzo[f][1,3,5]triazepine-2,4(3H,5H)-dione
CAS No.:1384248-79-6
Molecular Formula:C₂₂H₂₅N₅O₃
Molecular Weight:407.472
Hs Code.:

Synonyms:3-methyl-1-(2-(4-methylpiperazin-1-yl)-2-oxoethyl)-5-phenyl-1H-benzo[f][1,3,5]triazepine-2,4(3H,5H)-dione

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Chemical Property of 3-methyl-1-(2-(4-methylpiperazin-1-yl)-2-oxoethyl)-5-phenyl-1H-benzo[f][1,3,5]triazepine-2,4(3H,5H)-dione

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Technology Process of 3-methyl-1-(2-(4-methylpiperazin-1-yl)-2-oxoethyl)-5-phenyl-1H-benzo[f][1,3,5]triazepine-2,4(3H,5H)-dione

There total 6 articles about 3-methyl-1-(2-(4-methylpiperazin-1-yl)-2-oxoethyl)-5-phenyl-1H-benzo[f][1,3,5]triazepine-2,4(3H,5H)-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 48.0%

: 109-01-3
1-methyl-piperazine

: 1384248-74-1
2-(3-methyl-2,4-dioxo-5-phenyl-2,3,4,5-tetrahydro-1H-benzo[f][1,3,5]triazepin-1-yl)acetic acid

: 1384248-79-6
3-methyl-1-(2-(4-methylpiperazin-1-yl)-2-oxoethyl)-5-phenyl-1H-benzo[f][1,3,5]triazepine-2,4(3H,5H)-dione

Guidance literature:: With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; HATU; In N,N-dimethyl-formamide; at 20 ℃;
DOI:10.1016/j.tetlet.2012.05.025

Reference yield:

: 1394834-09-3
benzyl 2-(3-methyl-2,4-dioxo-5-phenyl-2,3,4,5-tetrahydro-1H-benzo[f][1,3,5]triazepin-1-yl)acetate

: 1384248-79-6
3-methyl-1-(2-(4-methylpiperazin-1-yl)-2-oxoethyl)-5-phenyl-1H-benzo[f][1,3,5]triazepine-2,4(3H,5H)-dione

Guidance literature:: Multi-step reaction with 2 steps

1: trifluoroacetic acid / dichloromethane / 20 °C

2: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; HATU / N,N-dimethyl-formamide / 20 °C

With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; HATU; trifluoroacetic acid; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.tetlet.2012.05.025

Reference yield:

: 1384248-61-6
benzyl 2-(2-(phenylamino)phenylamino)acetate

: 1384248-79-6
3-methyl-1-(2-(4-methylpiperazin-1-yl)-2-oxoethyl)-5-phenyl-1H-benzo[f][1,3,5]triazepine-2,4(3H,5H)-dione

Guidance literature:: Multi-step reaction with 4 steps

1.1: 2,4-dichlorophenoxyacetic acid dimethylamine / 0.5 h / 150 °C / Microwave irradiation

2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 20 °C

2.2: 16 h

3.1: trifluoroacetic acid / dichloromethane / 20 °C

4.1: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; HATU / N,N-dimethyl-formamide / 20 °C

With dmap; sodium hydride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; HATU; trifluoroacetic acid; In dichloromethane; 2,4-dichlorophenoxyacetic acid dimethylamine; N,N-dimethyl-formamide; mineral oil;
DOI:10.1016/j.tetlet.2012.05.025