3-[4-(tert-butyldiphenylsilyloxymethyl)-3-hydroxy-1-methyl-2-oxoindolin-3-yl]propanoic acid

Base Information

• Chemical Name: 3-[4-(tert-butyldiphenylsilyloxymethyl)-3-hydroxy-1-methyl-2-oxoindolin-3-yl]propanoic acid
• CAS No.: 1131429-71-4
• Molecular Formula: C₂₉H₃₃NO₅Si
• Molecular Weight: 503.67
• Mol file: 1131429-71-4.mol

Synonyms:3-[4-(tert-butyldiphenylsilyloxymethyl)-3-hydroxy-1-methyl-2-oxoindolin-3-yl]propanoic acid

Chemical Property of 3-[4-(tert-butyldiphenylsilyloxymethyl)-3-hydroxy-1-methyl-2-oxoindolin-3-yl]propanoic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-[4-(tert-butyldiphenylsilyloxymethyl)-3-hydroxy-1-methyl-2-oxoindolin-3-yl]propanoic acid

There total 1 articles about 3-[4-(tert-butyldiphenylsilyloxymethyl)-3-hydroxy-1-methyl-2-oxoindolin-3-yl]propanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

3-[4-(tert-butyldiphenylsilyloxymethyl)-1-methylindol-3-yl]propanoic acid (1131429-69-0) → 3-[4-(tert-butyldiphenylsilyloxymethyl)-3-hydroxy-1-methyl-2-oxoindolin-3-yl]propanoic acid (1131429-71-4)

Guidance literature:

With oxalyl dichloride; dimethyl sulfoxide; In dichloromethane; at -78 - 20 ℃; Inert atmosphere;

DOI:10.1016/j.tet.2008.12.029

Reference yield: 91.0%

3-[4-(tert-butyldiphenylsilyloxymethyl)-3-hydroxy-1-methyl-2-oxoindolin-3-yl]propanoic acid (1131429-71-4) → 3-[4-(tert-butyldiphenylsilyloxymethyl)-3-hydroxy-1-methyl-2-oxoindolin-3-yl]propanoic acid lactone (1131429-73-6)

Guidance literature:

at 110 ℃; for 8h; under 0.1 Torr;

DOI:10.1016/j.tet.2008.12.029

upstream raw materials:

3-[4-(tert-butyldiphenylsilyloxymethyl)-1-methylindol-3-yl]propanoic acid

Downstream raw materials:

3-[4-(tert-butyldiphenylsilyloxymethyl)-3-hydroxy-1-methyl-2-oxoindolin-3-yl]propanoic acid lactone