Technology Process of 13-Aza-3-methoxy-18-nor-5,6-seco-estrone
There total 6 articles about 13-Aza-3-methoxy-18-nor-5,6-seco-estrone which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
hydrogen;
platinum(IV) oxide; acetic acid;
In
ethanol;
for 48h;
under 3102.9 Torr;
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 40 percent / diethyl azodicarboxylate, triphenylphosphine / tetrahydrofuran / 18 h / Ambient temperature
2: 58 percent / NaBH4 / aq. ethanol / 0 °C / 1) addition of 2N HCl in 15min intervalls over 5h 2) pH 3, 1h
3: 34 percent / PTS / benzene / 0.75 h / Heating
4: 40 percent / H2 / PtO2, acetic acid / ethanol / 48 h / 3102.9 Torr
With
sodium tetrahydroborate; hydrogen; triphenylphosphine; diethylazodicarboxylate;
platinum(IV) oxide; pyridinium p-toluenesulfonate; acetic acid;
In
tetrahydrofuran; ethanol; benzene;
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 79 percent / LAH / diethyl ether / 3 h / 0 °C
2: 40 percent / diethyl azodicarboxylate, triphenylphosphine / tetrahydrofuran / 18 h / Ambient temperature
3: 58 percent / NaBH4 / aq. ethanol / 0 °C / 1) addition of 2N HCl in 15min intervalls over 5h 2) pH 3, 1h
4: 34 percent / PTS / benzene / 0.75 h / Heating
5: 40 percent / H2 / PtO2, acetic acid / ethanol / 48 h / 3102.9 Torr
With
sodium tetrahydroborate; lithium aluminium tetrahydride; hydrogen; triphenylphosphine; diethylazodicarboxylate;
platinum(IV) oxide; pyridinium p-toluenesulfonate; acetic acid;
In
tetrahydrofuran; diethyl ether; ethanol; benzene;
