6-[4-(7-amino-5-methylpyrazolo[1,5-a]pyrimidin-2-yl)phenyl]-1-(4-methylbenzyl)-1H-thieno[3,2-d]pyrimidin-4-one

Base Information

Chemical Name:6-[4-(7-amino-5-methylpyrazolo[1,5-a]pyrimidin-2-yl)phenyl]-1-(4-methylbenzyl)-1H-thieno[3,2-d]pyrimidin-4-one
CAS No.:1276129-99-7
Molecular Formula:C₂₇H₂₂N₆OS
Molecular Weight:478.577
Hs Code.:

Synonyms:6-[4-(7-amino-5-methylpyrazolo[1,5-a]pyrimidin-2-yl)phenyl]-1-(4-methylbenzyl)-1H-thieno[3,2-d]pyrimidin-4-one

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Chemical Property of 6-[4-(7-amino-5-methylpyrazolo[1,5-a]pyrimidin-2-yl)phenyl]-1-(4-methylbenzyl)-1H-thieno[3,2-d]pyrimidin-4-one

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Technology Process of 6-[4-(7-amino-5-methylpyrazolo[1,5-a]pyrimidin-2-yl)phenyl]-1-(4-methylbenzyl)-1H-thieno[3,2-d]pyrimidin-4-one

There total 4 articles about 6-[4-(7-amino-5-methylpyrazolo[1,5-a]pyrimidin-2-yl)phenyl]-1-(4-methylbenzyl)-1H-thieno[3,2-d]pyrimidin-4-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₂₆H₂₃N₅O₂S

: 77287-34-4,77287-35-5,60100-09-6
formamide

: 1276129-99-7
6-[4-(7-amino-5-methylpyrazolo[1,5-a]pyrimidin-2-yl)phenyl]-1-(4-methylbenzyl)-1H-thieno[3,2-d]pyrimidin-4-one

Guidance literature:: With sodium methylate; In methanol; N,N-dimethyl-formamide; at 100 ℃;

Reference yield:

: 942589-62-0
5-methyl-2-[4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)phenyl]pyrazolo[1,5-a]pyrimidin-7-ylamine

: 1276129-99-7
6-[4-(7-amino-5-methylpyrazolo[1,5-a]pyrimidin-2-yl)phenyl]-1-(4-methylbenzyl)-1H-thieno[3,2-d]pyrimidin-4-one

Guidance literature:: Multi-step reaction with 4 steps

1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide; water / 3 h / 100 °C

2: potassium carbonate; water / methanol

3: acetic acid; sodium tris(acetoxy)borohydride / dichloromethane / 0 - 20 °C

4: sodium methylate / N,N-dimethyl-formamide; methanol / 100 °C

With water; sodium methylate; sodium tris(acetoxy)borohydride; sodium carbonate; potassium carbonate; acetic acid; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In methanol; dichloromethane; water; N,N-dimethyl-formamide;

Reference yield:

: C₂₀H₁₄F₃N₅O₃S

: 1276129-99-7
6-[4-(7-amino-5-methylpyrazolo[1,5-a]pyrimidin-2-yl)phenyl]-1-(4-methylbenzyl)-1H-thieno[3,2-d]pyrimidin-4-one

Guidance literature:: Multi-step reaction with 3 steps

1: potassium carbonate; water / methanol

2: acetic acid; sodium tris(acetoxy)borohydride / dichloromethane / 0 - 20 °C

3: sodium methylate / N,N-dimethyl-formamide; methanol / 100 °C

With water; sodium methylate; sodium tris(acetoxy)borohydride; potassium carbonate; acetic acid; In methanol; dichloromethane; N,N-dimethyl-formamide;