Technology Process of C22H28ClNO2
There total 9 articles about C22H28ClNO2 which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
palladium on activated charcoal; hydrogen;
In
methanol;
at 20 ℃;
for 8h;
under 760.051 Torr;
DOI:10.1021/jm400102x
- Guidance literature:
-
Multi-step reaction with 4 steps
1: tetrahydrofuran; diethyl ether / 4 h / -78 - 0 °C
2: thionyl chloride / tetrahydrofuran / 2 h / 20 °C
3: di-isopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran / 8 h / 20 °C
4: hydrogen; palladium on activated charcoal / methanol / 8 h / 20 °C / 760.05 Torr
With
thionyl chloride; di-isopropyl azodicarboxylate; palladium on activated charcoal; hydrogen; triphenylphosphine;
In
tetrahydrofuran; methanol; diethyl ether;
3: |Mitsunobu Displacement;
DOI:10.1021/jm400102x
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: ammonia / methanol / 8 h / Reflux; Sealed tube
2.1: sodium / ethanol / 1 h
2.2: 96 h / Reflux
3.1: silver (II) carbonate / tetrahydrofuran / 8 h / 60 °C
4.1: tetrahydrofuran; diethyl ether / 4 h / -78 - 0 °C
5.1: thionyl chloride / tetrahydrofuran / 2 h / 20 °C
6.1: di-isopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran / 8 h / 20 °C
7.1: hydrogen; palladium on activated charcoal / methanol / 8 h / 20 °C / 760.05 Torr
With
silver (II) carbonate; thionyl chloride; di-isopropyl azodicarboxylate; palladium on activated charcoal; ammonia; hydrogen; sodium; triphenylphosphine;
In
tetrahydrofuran; methanol; diethyl ether; ethanol;
6.1: |Mitsunobu Displacement;
DOI:10.1021/jm400102x
