(S)-tert-butyl 2-allyl-3-(2-(3-(3-iodophenyl)-1-((4-methoxyphenyl)(methyl)amino)-1-oxopropan-2-ylamino)-2-oxoethyl)-1H-indole-1-carboxylate

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Chemical Name:(S)-tert-butyl 2-allyl-3-(2-(3-(3-iodophenyl)-1-((4-methoxyphenyl)(methyl)amino)-1-oxopropan-2-ylamino)-2-oxoethyl)-1H-indole-1-carboxylate
CAS No.:1620084-28-7
Molecular Formula:C₃₅H₃₈IN₃O₅
Molecular Weight:707.608
Hs Code.:

Synonyms:(S)-tert-butyl 2-allyl-3-(2-(3-(3-iodophenyl)-1-((4-methoxyphenyl)(methyl)amino)-1-oxopropan-2-ylamino)-2-oxoethyl)-1H-indole-1-carboxylate

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Chemical Property of (S)-tert-butyl 2-allyl-3-(2-(3-(3-iodophenyl)-1-((4-methoxyphenyl)(methyl)amino)-1-oxopropan-2-ylamino)-2-oxoethyl)-1H-indole-1-carboxylate

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Technology Process of (S)-tert-butyl 2-allyl-3-(2-(3-(3-iodophenyl)-1-((4-methoxyphenyl)(methyl)amino)-1-oxopropan-2-ylamino)-2-oxoethyl)-1H-indole-1-carboxylate

There total 8 articles about (S)-tert-butyl 2-allyl-3-(2-(3-(3-iodophenyl)-1-((4-methoxyphenyl)(methyl)amino)-1-oxopropan-2-ylamino)-2-oxoethyl)-1H-indole-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1620084-27-6
C₁₇H₁₉IN₂O₂*C₂HF₃O₂

: 1620084-29-8
2-(2-allyl-1-(tert-butoxycarbonyl)-1H-indol-3-yl)acetic acid

: 1620084-28-7
(S)-tert-butyl 2-allyl-3-(2-(3-(3-iodophenyl)-1-((4-methoxyphenyl)(methyl)amino)-1-oxopropan-2-ylamino)-2-oxoethyl)-1H-indole-1-carboxylate

Guidance literature:: 2-(2-allyl-1-(tert-butoxycarbonyl)-1H-indol-3-yl)acetic acid; With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In N,N-dimethyl-formamide; for 0.166667h;

C₁₇H₁₉IN₂O₂*C₂HF₃O₂; In N,N-dimethyl-formamide; at 20 ℃; for 2h;

Reference yield:

: 1198570-69-2
tert-butyl 2-bromo-3-(2-ethoxy-2-oxoethyl)-1H-indole-1-carboxylate

: 1620084-28-7
(S)-tert-butyl 2-allyl-3-(2-(3-(3-iodophenyl)-1-((4-methoxyphenyl)(methyl)amino)-1-oxopropan-2-ylamino)-2-oxoethyl)-1H-indole-1-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / 6 h / 80 °C / Inert atmosphere

2.1: lithium hydroxide; water / methanol; tetrahydrofuran / 2 h

3.1: N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 0.17 h

3.2: 2 h / 20 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; water; N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; lithium hydroxide; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;

Reference yield:

: 1620084-59-4
tert-butyl 2-allyl-3-(2-ethoxy-2-oxoethyl)-1H-indole-1-carboxylate

: 1620084-28-7
(S)-tert-butyl 2-allyl-3-(2-(3-(3-iodophenyl)-1-((4-methoxyphenyl)(methyl)amino)-1-oxopropan-2-ylamino)-2-oxoethyl)-1H-indole-1-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1.1: lithium hydroxide; water / methanol; tetrahydrofuran / 2 h

2.1: N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 0.17 h

2.2: 2 h / 20 °C

With water; N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; lithium hydroxide; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;