N-[1-(4-methanesulfonyl-6-phenoxy-hexahydro-pyrrolo[3,2-b]pyrrole-1-carbonyl)-2-methyl-propyl]-2-methylamino-propionamide

Base Information

Chemical Name:N-[1-(4-methanesulfonyl-6-phenoxy-hexahydro-pyrrolo[3,2-b]pyrrole-1-carbonyl)-2-methyl-propyl]-2-methylamino-propionamide
CAS No.:1257233-22-9
Molecular Formula:C₂₂H₃₄N₄O₅S
Molecular Weight:466.602
Hs Code.:

Synonyms:N-[1-(4-methanesulfonyl-6-phenoxy-hexahydro-pyrrolo[3,2-b]pyrrole-1-carbonyl)-2-methyl-propyl]-2-methylamino-propionamide

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Chemical Property of N-[1-(4-methanesulfonyl-6-phenoxy-hexahydro-pyrrolo[3,2-b]pyrrole-1-carbonyl)-2-methyl-propyl]-2-methylamino-propionamide

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Technology Process of N-[1-(4-methanesulfonyl-6-phenoxy-hexahydro-pyrrolo[3,2-b]pyrrole-1-carbonyl)-2-methyl-propyl]-2-methylamino-propionamide

There total 23 articles about N-[1-(4-methanesulfonyl-6-phenoxy-hexahydro-pyrrolo[3,2-b]pyrrole-1-carbonyl)-2-methyl-propyl]-2-methylamino-propionamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1257234-86-8
C₃₀H₄₀N₄O₇S

: 1257233-22-9
N-[1-(4-methanesulfonyl-6-phenoxy-hexahydro-pyrrolo[3,2-b]pyrrole-1-carbonyl)-2-methyl-propyl]-2-methylamino-propionamide

Guidance literature:: With hydrogen; palladium 10% on activated carbon; In methanol; for 1h; under 2585.81 Torr;

Reference yield:

: 1245724-76-8
N-Boc-4R-O-TBS-2R-aminoethyl-pyrrolidine

: 1257233-22-9
N-[1-(4-methanesulfonyl-6-phenoxy-hexahydro-pyrrolo[3,2-b]pyrrole-1-carbonyl)-2-methyl-propyl]-2-methylamino-propionamide

Guidance literature:: Multi-step reaction with 18 steps

1.1: dichloromethane / 0 - 20 °C

2.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 0 °C

3.1: sulfur trioxide pyridine complex; triethylamine / dichloromethane; dimethyl sulfoxide / 0 - 20 °C

4.1: sodium hexamethyldisilazane / tetrahydrofuran / -78 °C

5.1: borane / tetrahydrofuran / -30 - 0 °C

5.2: -10 - 0 °C

6.1: N-ethyl-N,N-diisopropylamine / dmap / dichloromethane / 0 °C

7.1: hydrogen / palladium 10% on activated carbon / methanol / 3 h

8.1: sodium acetate / 85 - 90 °C

9.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 0 - 20 °C

10.1: pyridine hydrogenfluoride / tetrahydrofuran / 0 - 20 °C

11.1: di-isopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran / 75 °C

12.1: hydrogen / 5%-palladium/activated carbon / methanol / 1 h / 2585.81 Torr

13.1: N-ethyl-N,N-diisopropylamine; HATU / 1-methyl-pyrrolidin-2-one / 0 - 20 °C

14.1: hydrogen / palladium 10% on activated carbon / methanol / 2 h / 2585.81 Torr

15.1: N-ethyl-N,N-diisopropylamine; HATU / 1-methyl-pyrrolidin-2-one / 0 - 20 °C

16.1: trifluoroacetic acid / dichloromethane / 0 °C

17.1: N-ethyl-N,N-diisopropylamine / dmap / dichloromethane / 0 °C

18.1: hydrogen / palladium 10% on activated carbon / methanol / 1 h / 2585.81 Torr

With di-isopropyl azodicarboxylate; borane; tetrabutyl ammonium fluoride; hydrogen; sodium acetate; sodium hexamethyldisilazane; sulfur trioxide pyridine complex; pyridine hydrogenfluoride; triethylamine; N-ethyl-N,N-diisopropylamine; triphenylphosphine; HATU; trifluoroacetic acid; dmap; 5%-palladium/activated carbon; palladium 10% on activated carbon; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; methanol; dichloromethane; dimethyl sulfoxide;

Reference yield:

: 137934-80-6
4-(tert-butyl-dimethyl-silanyloxy)-2-(2-nitro-vinyl)-pyrrolidine-1-carboxylic acid tert-butyl ester

: 1257233-22-9
N-[1-(4-methanesulfonyl-6-phenoxy-hexahydro-pyrrolo[3,2-b]pyrrole-1-carbonyl)-2-methyl-propyl]-2-methylamino-propionamide

Guidance literature:: Multi-step reaction with 20 steps

1.1: sodium tetrahydroborate / tetrahydrofuran; water / -20 °C

2.1: hydrogen / Raney nickel / ethanol; water / 1 h / 2844.39 Torr

3.1: dichloromethane / 0 - 20 °C

4.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 0 °C

5.1: sulfur trioxide pyridine complex; triethylamine / dichloromethane; dimethyl sulfoxide / 0 - 20 °C

6.1: sodium hexamethyldisilazane / tetrahydrofuran / -78 °C

7.1: borane / tetrahydrofuran / -30 - 0 °C

7.2: -10 - 0 °C

8.1: N-ethyl-N,N-diisopropylamine / dmap / dichloromethane / 0 °C

9.1: hydrogen / palladium 10% on activated carbon / methanol / 3 h

10.1: sodium acetate / 85 - 90 °C

11.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 0 - 20 °C

12.1: pyridine hydrogenfluoride / tetrahydrofuran / 0 - 20 °C

13.1: di-isopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran / 75 °C

14.1: hydrogen / 5%-palladium/activated carbon / methanol / 1 h / 2585.81 Torr

15.1: N-ethyl-N,N-diisopropylamine; HATU / 1-methyl-pyrrolidin-2-one / 0 - 20 °C

16.1: hydrogen / palladium 10% on activated carbon / methanol / 2 h / 2585.81 Torr

17.1: N-ethyl-N,N-diisopropylamine; HATU / 1-methyl-pyrrolidin-2-one / 0 - 20 °C

18.1: trifluoroacetic acid / dichloromethane / 0 °C

19.1: N-ethyl-N,N-diisopropylamine / dmap / dichloromethane / 0 °C

20.1: hydrogen / palladium 10% on activated carbon / methanol / 1 h / 2585.81 Torr

With sodium tetrahydroborate; di-isopropyl azodicarboxylate; borane; tetrabutyl ammonium fluoride; hydrogen; sodium acetate; sodium hexamethyldisilazane; sulfur trioxide pyridine complex; pyridine hydrogenfluoride; triethylamine; N-ethyl-N,N-diisopropylamine; triphenylphosphine; HATU; trifluoroacetic acid; dmap; 5%-palladium/activated carbon; palladium 10% on activated carbon; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; methanol; ethanol; dichloromethane; water; dimethyl sulfoxide;