(2S,3R)-3-fluoro-3-{2-[(S)-p-tolylsulfinyl]phenyl}-2-(4-methoxyphenyl)prop-1-yl phenyl sulfone

Base Information

Chemical Name:(2S,3R)-3-fluoro-3-{2-[(S)-p-tolylsulfinyl]phenyl}-2-(4-methoxyphenyl)prop-1-yl phenyl sulfone
CAS No.:1363721-92-9
Molecular Formula:C₂₉H₂₇FO₄S₂
Molecular Weight:522.661
Hs Code.:

Synonyms:(2S,3R)-3-fluoro-3-{2-[(S)-p-tolylsulfinyl]phenyl}-2-(4-methoxyphenyl)prop-1-yl phenyl sulfone

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Chemical Property of (2S,3R)-3-fluoro-3-{2-[(S)-p-tolylsulfinyl]phenyl}-2-(4-methoxyphenyl)prop-1-yl phenyl sulfone

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Technology Process of (2S,3R)-3-fluoro-3-{2-[(S)-p-tolylsulfinyl]phenyl}-2-(4-methoxyphenyl)prop-1-yl phenyl sulfone

There total 2 articles about (2S,3R)-3-fluoro-3-{2-[(S)-p-tolylsulfinyl]phenyl}-2-(4-methoxyphenyl)prop-1-yl phenyl sulfone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 1311404-00-8
1-(fluoromethyl)-2-[(S)-p-tolylsulfinyl]benzene

: 87891-80-3,126079-49-0,69520-11-2
1-methoxy-4-(2-(phenylsulfonyl)vinyl)benzene

: 1363721-82-7
(2R,3R)-3-fluoro-3-{2-[(S)-p-tolylsulfinyl]phenyl}-2-(4-methoxyphenyl)prop-1-yl phenyl sulfone

: 1363721-92-9
(2S,3R)-3-fluoro-3-{2-[(S)-p-tolylsulfinyl]phenyl}-2-(4-methoxyphenyl)prop-1-yl phenyl sulfone

Guidance literature:: 1-(fluoromethyl)-2-[(S)-p-tolylsulfinyl]benzene; With n-butyllithium; diisopropylamine; In tetrahydrofuran; hexane; at -78 ℃; for 0.0833333h; Inert atmosphere;

1-methoxy-4-(2-(phenylsulfonyl)vinyl)benzene; In tetrahydrofuran; hexane; at -78 ℃; for 0.0166667h; optical yield given as %de; diastereoselective reaction; Inert atmosphere;
DOI:10.1021/jo300174k

Reference yield:

: C₂₀H₁₈O₄S₂

: 1363721-82-7
(2R,3R)-3-fluoro-3-{2-[(S)-p-tolylsulfinyl]phenyl}-2-(4-methoxyphenyl)prop-1-yl phenyl sulfone

: 1363721-92-9
(2S,3R)-3-fluoro-3-{2-[(S)-p-tolylsulfinyl]phenyl}-2-(4-methoxyphenyl)prop-1-yl phenyl sulfone

Guidance literature:: Multi-step reaction with 2 steps

1.1: cesium fluoride / acetonitrile / Ionic liquid; Inert atmosphere

2.1: n-butyllithium; diisopropylamine / tetrahydrofuran; hexane / 0.08 h / -78 °C / Inert atmosphere

2.2: 0.02 h / -78 °C / Inert atmosphere

With n-butyllithium; diisopropylamine; cesium fluoride; In tetrahydrofuran; hexane; acetonitrile; 2.1: Michael condensation / 2.2: Michael condensation;
DOI:10.1021/jo300174k