17-(Cyclopropylmethyl)morphinan-6-one

Base Information

Chemical Name:17-(Cyclopropylmethyl)morphinan-6-one
CAS No.:112246-80-7
Molecular Formula:C₂₀H₂₅NO
Molecular Weight:295.425
Hs Code.:
DSSTox Substance ID:DTXSID30920707
Wikidata:Q82893387
Mol file:112246-80-7.mol

Synonyms:cPrMMO;N-cyclopropylmethylmorphinan-6-one

Suppliers and Price of 17-(Cyclopropylmethyl)morphinan-6-one

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 2 raw suppliers

Chemical Property of 17-(Cyclopropylmethyl)morphinan-6-one

Chemical Property:

Vapor Pressure:3.21E-08mmHg at 25°C
Boiling Point:448°C at 760 mmHg
Flash Point:211.1°C
PSA：20.31000
Density:1.18g/cm³
LogP:3.27190
XLogP3:3.1
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:2
Exact Mass:295.193614421
Heavy Atom Count:22
Complexity:470

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1CC1CN2CCC34CC(=O)CCC3C2CC5=CC=CC=C45
Isomeric SMILES:C1CC(=O)C[C@@]23[C@@H]1[C@@H](CC4=CC=CC=C42)N(CC3)CC5CC5

Technology Process of 17-(Cyclopropylmethyl)morphinan-6-one

There total 4 articles about 17-(Cyclopropylmethyl)morphinan-6-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 81451-69-6
(-)-Morphinan-6-one hydrochloride

: 5911-08-0
chloro(cyclopropyl)methane

: 112246-80-7
(-)-17-Cyclopropylmethylmorphinan-6-one

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 100 ℃; for 16h;
DOI:10.1002/ardp.19903230108

Reference yield:

: 81451-64-1
(-)-N-methylmorphinan-6-one

: 112246-80-7
(-)-17-Cyclopropylmethylmorphinan-6-one

Guidance literature:: Multi-step reaction with 4 steps

1: 2.78 g / 1,2-dichloro-ethane / 60 h / 60 - 65 °C

2: HCl / CH₂Cl₂ / Ambient temperature

3: methanol / 1 h / Heating

4: 1.64 g / K₂CO₃ / dimethylformamide / 16 h / 100 °C

With hydrogenchloride; potassium carbonate; In methanol; dichloromethane; 1,2-dichloro-ethane; N,N-dimethyl-formamide;
DOI:10.1002/ardp.19903230108

Reference yield:

: 127322-15-0
C₁₉H₂₁NO₃

: 112246-80-7
(-)-17-Cyclopropylmethylmorphinan-6-one

Guidance literature:: Multi-step reaction with 3 steps

1: HCl / CH₂Cl₂ / Ambient temperature

2: methanol / 1 h / Heating

3: 1.64 g / K₂CO₃ / dimethylformamide / 16 h / 100 °C

With hydrogenchloride; potassium carbonate; In methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1002/ardp.19903230108