6-[(2R,4S)-2-(2-chlorophenoxymethyl)-4-fluoropyrrolidin-1-yl]-9H-purine

Base Information

Chemical Name:6-[(2R,4S)-2-(2-chlorophenoxymethyl)-4-fluoropyrrolidin-1-yl]-9H-purine
CAS No.:1201580-69-9
Molecular Formula:C₁₆H₁₅ClFN₅O
Molecular Weight:347.779
Hs Code.:

Synonyms:6-[(2R,4S)-2-(2-chlorophenoxymethyl)-4-fluoropyrrolidin-1-yl]-9H-purine

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Chemical Property of 6-[(2R,4S)-2-(2-chlorophenoxymethyl)-4-fluoropyrrolidin-1-yl]-9H-purine

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Technology Process of 6-[(2R,4S)-2-(2-chlorophenoxymethyl)-4-fluoropyrrolidin-1-yl]-9H-purine

There total 6 articles about 6-[(2R,4S)-2-(2-chlorophenoxymethyl)-4-fluoropyrrolidin-1-yl]-9H-purine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1201581-82-9
(2R,4S)-2-(2-chlorophenoxymethyl)-4-fluoropyrrolidine

: 87-42-3
6-chloropurine

: 1201580-69-9
6-[(2R,4S)-2-(2-chlorophenoxymethyl)-4-fluoropyrrolidin-1-yl]-9H-purine

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In butan-1-ol; at 120 ℃; for 6h; under 7500.75 Torr; Microwave irradiation;

Reference yield:

: 1201581-81-8
tert-butyl (2R,4S)-2-(2-chlorophenoxymethyl)-4-fluoropyrrolidine-1-carboxylate

: 1201580-69-9
6-[(2R,4S)-2-(2-chlorophenoxymethyl)-4-fluoropyrrolidin-1-yl]-9H-purine

Guidance literature:: Multi-step reaction with 2 steps

1: hydrogenchloride / ethanol; tetrahydrofuran / 2 h / 80 °C

2: N-ethyl-N,N-diisopropylamine / butan-1-ol / 6 h / 120 °C / 7500.75 Torr / Microwave irradiation

With hydrogenchloride; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; ethanol; butan-1-ol;

Reference yield:

: 2584-71-6,30724-02-8
cis-hydroxy-D-proline

: 1201580-69-9
6-[(2R,4S)-2-(2-chlorophenoxymethyl)-4-fluoropyrrolidin-1-yl]-9H-purine

Guidance literature:: Multi-step reaction with 8 steps

1: thionyl chloride / 13 h / 0 - 20 °C

2: dmap; triethylamine / dichloromethane / 12 h / 20 °C

3: diethylamino-sulfur trifluoride / dichloromethane / 12 h / -78 - 20 °C / Inert atmosphere

4: lithium borohydride / tetrahydrofuran / 6 h / -20 - 20 °C

5: triethylamine / dichloromethane / 4 h / 0 - 20 °C

6: caesium carbonate / N,N-dimethyl-formamide / 12 h / 80 °C

7: hydrogenchloride / ethanol; tetrahydrofuran / 2 h / 80 °C

8: N-ethyl-N,N-diisopropylamine / butan-1-ol / 6 h / 120 °C / 7500.75 Torr / Microwave irradiation

With hydrogenchloride; dmap; lithium borohydride; thionyl chloride; diethylamino-sulfur trifluoride; caesium carbonate; triethylamine; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; ethanol; dichloromethane; N,N-dimethyl-formamide; butan-1-ol;