(2R)-3-bromo-N-(3-chloro-4-cyanophenyl)-2-hydroxy-2-methylpropanamide

Base Information

• Chemical Name: (2R)-3-bromo-N-(3-chloro-4-cyanophenyl)-2-hydroxy-2-methylpropanamide
• CAS No.: 1002330-78-0
• Molecular Formula: C₁₁H₁₀BrClN₂O₂
• Molecular Weight: 317.57
• Mol file: 1002330-78-0.mol

Synonyms:(2R)-3-bromo-N-(3-chloro-4-cyanophenyl)-2-hydroxy-2-methylpropanamide

Chemical Property of (2R)-3-bromo-N-(3-chloro-4-cyanophenyl)-2-hydroxy-2-methylpropanamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (2R)-3-bromo-N-(3-chloro-4-cyanophenyl)-2-hydroxy-2-methylpropanamide

There total 4 articles about (2R)-3-bromo-N-(3-chloro-4-cyanophenyl)-2-hydroxy-2-methylpropanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.6%

4-amino-2-chlorobenzonitrile (20925-27-3) + (2R)-3-bromo-2-hydroxy-2-methylpropanoic acid (261904-39-6) → (2R)-3-bromo-N-(3-chloro-4-cyanophenyl)-2-hydroxy-2-methylpropanamide (1002330-78-0)

Guidance literature:

(2R)-3-bromo-2-hydroxy-2-methylpropanoic acid; With thionyl chloride; In tetrahydrofuran; at 0 - 12 ℃; for 2.166h;

With triethylamine; In tetrahydrofuran; at -5 - 12 ℃; for 0.333333h;

4-amino-2-chlorobenzonitrile; In tetrahydrofuran; at 50 ℃; for 2h;

Reference yield:

4-amino-2-chlorobenzonitrile (20925-27-3) + (R)-3-bromo-2-hydroxy-2-methylpropanoyl chloride (1010396-30-1) → (2R)-3-bromo-N-(3-chloro-4-cyanophenyl)-2-hydroxy-2-methylpropanamide (1002330-78-0)

Guidance literature:

With triethylamine; In tetrahydrofuran; at 20 ℃;

Reference yield:

4-amino-2-chlorobenzonitrile (20925-27-3) → (2R)-3-bromo-N-(3-chloro-4-cyanophenyl)-2-hydroxy-2-methylpropanamide (1002330-78-0)

Guidance literature:

(R)-3-bromo-2-hydroxy-2-methylpropanoyl chloride; With triethylamine; In tetrahydrofuran; at 4 ℃; for 0.333333h;

4-amino-2-chlorobenzonitrile; In tetrahydrofuran; at 20 ℃;

upstream raw materials:

4-amino-2-chlorobenzonitrile

(R)-3-bromo-2-hydroxy-2-methylpropanoyl chloride

(2R)-3-bromo-2-hydroxy-2-methylpropanoic acid

(R)-3-bromo-2-hydroxy-2-methylpropanoic acid

Downstream raw materials:

(S)-N-(3-chloro-4-cyanophenyl)-2-methyloxirane-2-carboxamide

((S)-N-(3-chloro-4-cyanophenyl)-3-(4-cyanophenoxy)-2-hydroxy-2-methylpropanamide)

(S)-N-(3-chloro-4-cyanophenyl)-3-(4-cyanophenoxy)-2-hydroxy-2-methylpropanamide-d4