2-methoxyhippurohydroxamic acid

Base Information

• Chemical Name: 2-methoxyhippurohydroxamic acid
• CAS No.: 65654-09-3
• Molecular Formula: C10H12N2O4
• Molecular Weight: 224.21
• Mol file: 65654-09-3.mol

Synonyms:2-Methoxyhippurohydroxamic acid;2-(meta-Methoxybenzamid)-acetohydroxamsaeure;ACETOHYDROXAMIC ACID,2-(m-METHOXYBENZAMIDO);Benzamide,N-(2-(hydroxyamino)-2-oxoethyl)-3-methoxy;2-(m-Methoxybenzamido)acetohydroxamic acid;

Chemical Property of 2-methoxyhippurohydroxamic acid

Chemical Property:

• PSA: 94.64000
• Density: 1.29g/cm³
• LogP: 1.34550

Purity/Quality:

99%min ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-methoxyhippurohydroxamic acid

There total 5 articles about 2-methoxyhippurohydroxamic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C18H17N2O5Pol → 2-(meta-Methoxybenzamid)-acetohydroxamsaeure (65654-09-3)

Guidance literature:

With hydroxylamine; sodium hydroxide; In water; isopropyl alcohol; for 15h; Inert atmosphere; solid phase reaction;

DOI:10.1016/j.tetlet.2011.10.103

Reference yield:

ethyl 2-(3-methoxybenzamido) acetate (65654-29-7) → 2-(meta-Methoxybenzamid)-acetohydroxamsaeure (65654-09-3)

Guidance literature:

With potassium hydroxide; hydroxylamine hydrochloride; In methanol; Yield given; Ambient temperature;

DOI:10.1248/cpb.28.2045

Reference yield:

m-anisoyl chloride (1711-05-3) → 2-(meta-Methoxybenzamid)-acetohydroxamsaeure (65654-09-3)

Guidance literature:

Multi-step reaction with 2 steps

1: K₂CO₃ / H₂O; toluene / -5 - 5 °C

2: NH₂OH*HCl, KOH / methanol / Ambient temperature

With potassium hydroxide; hydroxylamine hydrochloride; potassium carbonate; In methanol; water; toluene;

DOI:10.1248/cpb.28.2045

upstream raw materials:

ethyl 2-(3-methoxybenzamido) acetate

m-anisoyl chloride

3-Methoxybenzoic acid

Refernces

• 1、 Munakata,Tanaka,Toyoshima. "Therapy for urolithiasis with hydroxamic acids. I. Synthesis of new N-(aroyl)glycinohydroxamic acid derivatives and related compounds". . p. 2045 - 2051. Retrieved 2007/10/02.