5-(benzyloxy)-3-(tert-butyloxycarbonyl)-1-(chloromethyl)-1,2-dihydro-3H-pyrrolo[3,2-e]indole

Base Information

• Chemical Name: 5-(benzyloxy)-3-(tert-butyloxycarbonyl)-1-(chloromethyl)-1,2-dihydro-3H-pyrrolo[3,2-e]indole
• CAS No.: 227084-68-6
• Molecular Formula: C₂₃H₂₅ClN₂O₃
• Molecular Weight: 412.916

Synonyms:5-(benzyloxy)-3-(tert-butyloxycarbonyl)-1-(chloromethyl)-1,2-dihydro-3H-pyrrolo[3,2-e]indole

Chemical Property of 5-(benzyloxy)-3-(tert-butyloxycarbonyl)-1-(chloromethyl)-1,2-dihydro-3H-pyrrolo[3,2-e]indole

Chemical Property:

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Technology Process of 5-(benzyloxy)-3-(tert-butyloxycarbonyl)-1-(chloromethyl)-1,2-dihydro-3H-pyrrolo[3,2-e]indole

There total 12 articles about 5-(benzyloxy)-3-(tert-butyloxycarbonyl)-1-(chloromethyl)-1,2-dihydro-3H-pyrrolo[3,2-e]indole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

5-(benzyloxy)-1-(chloromethyl)-3,6-bis(tert-butyloxycarbonyl)-1,2-dihydro-3H-pyrrolo[3,2-e]indole (277317-35-8) → 5-(benzyloxy)-3-(tert-butyloxycarbonyl)-1-(chloromethyl)-1,2-dihydro-3H-pyrrolo[3,2-e]indole (227084-68-6)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; at 0 - 25 ℃; for 1.5h;

DOI:10.1021/jo000297j

Reference yield: 77.0%

(7-Benzyloxy-4-bromo-1H-indol-5-yl)-((E)-3-chloro-allyl)-carbamic acid tert-butyl ester → 5-(benzyloxy)-3-(tert-butyloxycarbonyl)-1-(chloromethyl)-1,2-dihydro-3H-pyrrolo[3,2-e]indole (227084-68-6)

Guidance literature:

With 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride; In toluene; at 90 ℃;

DOI:10.1016/S0040-4039(98)00232-9

Reference yield: 72.0%

(7-Benzyloxy-4-iodo-1H-indol-5-yl)-((E)-3-chloro-allyl)-carbamic acid tert-butyl ester → 5-(benzyloxy)-3-(tert-butyloxycarbonyl)-1-(chloromethyl)-1,2-dihydro-3H-pyrrolo[3,2-e]indole (227084-68-6)

Guidance literature:

With 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride; In toluene; at 90 ℃;

DOI:10.1016/S0040-4039(98)00232-9

upstream raw materials:

5-(benzyloxy)-1-(chloromethyl)-3,6-bis(tert-butyloxycarbonyl)-1,2-dihydro-3H-pyrrolo[3,2-e]indole

di-tert-butyl dicarbonate

N⁵,1-Dibenzoyl-5-amino-7-benzyloxyindole

5-(benzoylamino)-7-(benzyloxy)-4-iodoindole

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