diethyl benzyl(phenyl)phosphoramidate

Base Information

• Chemical Name: diethyl benzyl(phenyl)phosphoramidate
• CAS No.: 7006-55-5
• Molecular Formula: C₁₇H₂₂NO₃P
• Molecular Weight: 319.34
• Mol file: 7006-55-5.mol

Synonyms:diethyl benzyl(phenyl)phosphoramidate

Chemical Property of diethyl benzyl(phenyl)phosphoramidate

Chemical Property:

Purity/Quality:

Safty Information:

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• Hazard Codes: 

MSDS Files:

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Technology Process of diethyl benzyl(phenyl)phosphoramidate

There total 6 articles about diethyl benzyl(phenyl)phosphoramidate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

N-Benzylaniline (758640-21-0,103-32-2) + triethyl phosphite (122-52-1) → diethyl benzyl(phenyl)phosphoramidate (7006-55-5)

Guidance literature:

With oxygen; copper diacetate; tri tert-butylphosphoniumtetrafluoroborate; In acetonitrile; at 80 ℃; for 18h; under 760.051 Torr; Schlenk technique;

DOI:10.1002/ejoc.202100550

Reference yield:

benzylidene phenylamine (538-51-2) + phosphonic acid diethyl ester (762-04-9) → diethyl benzyl(phenyl)phosphoramidate (7006-55-5)

Guidance literature:

With iodine; In water; N,N-dimethyl-formamide; at 50 ℃; for 0.0416667h; Flow reactor; Automated synthesizer;

DOI:10.1002/chem.201602373

Reference yield:

aniline (62-53-3) → diethyl benzyl(phenyl)phosphoramidate (7006-55-5)

Guidance literature:

Multi-step reaction with 2 steps

1: methanol / 20 °C / Flow reactor; Automated synthesizer

2: iodine / N,N-dimethyl-formamide; water / 0.04 h / 50 °C / Flow reactor; Automated synthesizer

With iodine; In methanol; water; N,N-dimethyl-formamide; 2: |Pudovik Reaction;

DOI:10.1002/chem.201602373

upstream raw materials:

diethyl phenylphosphoramidate

benzyl chloride

aniline

benzylidene phenylamine