(4R)-cyclohexylmethoxypyrrolidine-1,(2S)-dicarboxylic acid 1-tert-butyl ester

Base Information

• Chemical Name: (4R)-cyclohexylmethoxypyrrolidine-1,(2S)-dicarboxylic acid 1-tert-butyl ester
• CAS No.: 147267-14-9
• Molecular Formula: C₁₇H₂₉NO₅
• Molecular Weight: 327.421
• Mol file: 147267-14-9.mol

Synonyms:(4R)-cyclohexylmethoxypyrrolidine-1,(2S)-dicarboxylic acid 1-tert-butyl ester

Chemical Property of (4R)-cyclohexylmethoxypyrrolidine-1,(2S)-dicarboxylic acid 1-tert-butyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (4R)-cyclohexylmethoxypyrrolidine-1,(2S)-dicarboxylic acid 1-tert-butyl ester

There total 3 articles about (4R)-cyclohexylmethoxypyrrolidine-1,(2S)-dicarboxylic acid 1-tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

(2S,4R)-4-(benzyloxy)-1-(tert-butoxycarbonyl)pyrrolidine-2-carboxylic acid (40350-83-2,54631-82-2,54631-81-1) → (4R)-cyclohexylmethoxypyrrolidine-1,(2S)-dicarboxylic acid 1-tert-butyl ester (147267-14-9)

Guidance literature:

With Rh/Al₂O₃; hydrogen; In isopropyl alcohol; at 20 ℃; for 24h;

DOI:10.1021/jm100839w

Reference yield:

(2S,4R)-4-hydroxy-1-[(2-methylpropan-2-yl)oxycarbonyl]pyrrolidine-2-carboxylic acid (13726-69-7,946610-68-0) + Cyclohexylmethyl bromide (2550-36-9) → (4R)-cyclohexylmethoxypyrrolidine-1,(2S)-dicarboxylic acid 1-tert-butyl ester (147267-14-9)

Guidance literature:

(2S,4R)-4-hydroxy-1-[(2-methylpropan-2-yl)oxycarbonyl]pyrrolidine-2-carboxylic acid; With potassium hydroxide; In dimethyl sulfoxide; at 0 ℃; for 0.333333h;

Cyclohexylmethyl bromide; at 0 - 20 ℃;

DOI:10.1016/j.bmcl.2008.08.029

Reference yield:

(2S,4R)-4-hydroxy-1-[(2-methylpropan-2-yl)oxycarbonyl]pyrrolidine-2-carboxylic acid (13726-69-7,946610-68-0) → (4R)-cyclohexylmethoxypyrrolidine-1,(2S)-dicarboxylic acid 1-tert-butyl ester (147267-14-9)

Guidance literature:

With potassium hydroxide; In dimethyl sulfoxide;

DOI:10.1016/0960-894X(96)00404-0

upstream raw materials:

(2S,4R)-4-hydroxy-1-[(2-methylpropan-2-yl)oxycarbonyl]pyrrolidine-2-carboxylic acid

Cyclohexylmethyl bromide

(2S,4R)-4-(benzyloxy)-1-(tert-butoxycarbonyl)pyrrolidine-2-carboxylic acid