2-(Naphthalene-1-sulfonylamino)-N-{[2-oxo-2-pyrrolidin-1-yl-1-(4-thiocarbamoyl-benzyl)-ethylcarbamoyl]-methyl}-acetamide

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Chemical Name:2-(Naphthalene-1-sulfonylamino)-N-{[2-oxo-2-pyrrolidin-1-yl-1-(4-thiocarbamoyl-benzyl)-ethylcarbamoyl]-methyl}-acetamide
CAS No.:93886-98-7
Molecular Formula:C₂₈H₃₁N₅O₅S₂
Molecular Weight:581.717
Hs Code.:

Synonyms:2-(Naphthalene-1-sulfonylamino)-N-{[2-oxo-2-pyrrolidin-1-yl-1-(4-thiocarbamoyl-benzyl)-ethylcarbamoyl]-methyl}-acetamide

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Chemical Property of 2-(Naphthalene-1-sulfonylamino)-N-{[2-oxo-2-pyrrolidin-1-yl-1-(4-thiocarbamoyl-benzyl)-ethylcarbamoyl]-methyl}-acetamide

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Technology Process of 2-(Naphthalene-1-sulfonylamino)-N-{[2-oxo-2-pyrrolidin-1-yl-1-(4-thiocarbamoyl-benzyl)-ethylcarbamoyl]-methyl}-acetamide

There total 7 articles about 2-(Naphthalene-1-sulfonylamino)-N-{[2-oxo-2-pyrrolidin-1-yl-1-(4-thiocarbamoyl-benzyl)-ethylcarbamoyl]-methyl}-acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 93886-86-3
N-{[1-(4-Cyano-benzyl)-2-oxo-2-pyrrolidin-1-yl-ethylcarbamoyl]-methyl}-2-(naphthalene-1-sulfonylamino)-acetamide

: 93886-98-7
2-(Naphthalene-1-sulfonylamino)-N-{[2-oxo-2-pyrrolidin-1-yl-1-(4-thiocarbamoyl-benzyl)-ethylcarbamoyl]-methyl}-acetamide

Guidance literature:: With TEA; hydrogen sulfide; In pyridine; Ambient temperature;

Reference yield:

: 92740-47-1
α-naphthylenesulfonylglycine

: 93886-98-7
2-(Naphthalene-1-sulfonylamino)-N-{[2-oxo-2-pyrrolidin-1-yl-1-(4-thiocarbamoyl-benzyl)-ethylcarbamoyl]-methyl}-acetamide

Guidance literature:: Multi-step reaction with 7 steps

1: SOCl₂ / 1 h / Heating

2: 2 M NaOH / CHCl₃; ethyl acetate / 10 h

3: 70 percent / DCC / pyridine; ethyl acetate / 1.) 2 h, 2.) 10 h, room temperature

4: 75 percent / Et₃N / pyridine; ethyl acetate / 2 h

5: DCC / pyridine; ethyl acetate / 1.) 2 h, 2.) 10 h, room temperature

6: CHCl₃ / 2 h

7: 85 percent / H₂S, TEA / pyridine / Ambient temperature

With sodium hydroxide; thionyl chloride; TEA; hydrogen sulfide; triethylamine; dicyclohexyl-carbodiimide; In pyridine; chloroform; ethyl acetate;

Reference yield:

: 93886-71-6
1-Naphthylsulfonylglycylglycin

: 93886-98-7
2-(Naphthalene-1-sulfonylamino)-N-{[2-oxo-2-pyrrolidin-1-yl-1-(4-thiocarbamoyl-benzyl)-ethylcarbamoyl]-methyl}-acetamide

Guidance literature:: Multi-step reaction with 5 steps

1: 70 percent / DCC / pyridine; ethyl acetate / 1.) 2 h, 2.) 10 h, room temperature

2: 75 percent / Et₃N / pyridine; ethyl acetate / 2 h

3: DCC / pyridine; ethyl acetate / 1.) 2 h, 2.) 10 h, room temperature

4: CHCl₃ / 2 h

5: 85 percent / H₂S, TEA / pyridine / Ambient temperature

With TEA; hydrogen sulfide; triethylamine; dicyclohexyl-carbodiimide; In pyridine; chloroform; ethyl acetate;