ethyl 4-[1-benzyloxycarbonyl-(3R)-methoxy-(2R)-pyrrolidinylmethoxy]benzote

Base Information

Chemical Name:ethyl 4-[1-benzyloxycarbonyl-(3R)-methoxy-(2R)-pyrrolidinylmethoxy]benzote
CAS No.:1416960-88-7
Molecular Formula:C₂₃H₂₇NO₆
Molecular Weight:413.47
Hs Code.:

Synonyms:ethyl 4-[1-benzyloxycarbonyl-(3R)-methoxy-(2R)-pyrrolidinylmethoxy]benzote

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Chemical Property of ethyl 4-[1-benzyloxycarbonyl-(3R)-methoxy-(2R)-pyrrolidinylmethoxy]benzote

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Technology Process of ethyl 4-[1-benzyloxycarbonyl-(3R)-methoxy-(2R)-pyrrolidinylmethoxy]benzote

There total 8 articles about ethyl 4-[1-benzyloxycarbonyl-(3R)-methoxy-(2R)-pyrrolidinylmethoxy]benzote which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 120-47-8
Ethyl 4-hydroxybenzoate

: 1416960-83-2
1-benzyloxycarbonyl-(3R)-methoxy-(2R)-pyrrolidinemethanol

: 1416960-88-7
ethyl 4-[1-benzyloxycarbonyl-(3R)-methoxy-(2R)-pyrrolidinylmethoxy]benzote

Guidance literature:: With di-isopropyl azodicarboxylate; triphenylphosphine; In tetrahydrofuran; for 7h; Reflux;
DOI:10.1016/j.bmc.2012.11.003

Reference yield:

: 1416960-81-0
1-benzyloxycarbonyl-(2R)-tert-butyldimethylsilyloxymethyl-3-pyrrolidinone

: 1416960-88-7
ethyl 4-[1-benzyloxycarbonyl-(3R)-methoxy-(2R)-pyrrolidinylmethoxy]benzote

Guidance literature:: Multi-step reaction with 4 steps

1: sodium tetrahydroborate / methanol / 7 h / -10 - 20 °C

2: sodium hydride / N,N-dimethyl-formamide / 13 h / 0 - 20 °C

3: tetrabutyl ammonium fluoride / tetrahydrofuran / 18 h / 0 - 20 °C

4: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 7 h / Reflux

With sodium tetrahydroborate; di-isopropyl azodicarboxylate; tetrabutyl ammonium fluoride; sodium hydride; triphenylphosphine; In tetrahydrofuran; methanol; N,N-dimethyl-formamide; 4: |Mitsunobu Displacement;
DOI:10.1016/j.bmc.2012.11.003

Reference yield:

: 1416960-93-4
1-benzyloxycarbonyl-(2R)-tert-butyldimethylsilyloxymethyl-(3R)-methoxypyrrolidine

: 1416960-88-7
ethyl 4-[1-benzyloxycarbonyl-(3R)-methoxy-(2R)-pyrrolidinylmethoxy]benzote

Guidance literature:: Multi-step reaction with 2 steps

1: tetrabutyl ammonium fluoride / tetrahydrofuran / 18 h / 0 - 20 °C

2: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 7 h / Reflux

With di-isopropyl azodicarboxylate; tetrabutyl ammonium fluoride; triphenylphosphine; In tetrahydrofuran; 2: |Mitsunobu Displacement;
DOI:10.1016/j.bmc.2012.11.003