methyl 4-(8-quinolinylcarbamoyl)-3,5-bis((triisopropylsilyl)ethynyl)benzoate

Base Information

Chemical Name:methyl 4-(8-quinolinylcarbamoyl)-3,5-bis((triisopropylsilyl)ethynyl)benzoate
CAS No.:1351067-12-3
Molecular Formula:C₄₀H₅₄N₂O₃Si₂
Molecular Weight:667.051
Hs Code.:

Synonyms:methyl 4-(8-quinolinylcarbamoyl)-3,5-bis((triisopropylsilyl)ethynyl)benzoate

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Chemical Property of methyl 4-(8-quinolinylcarbamoyl)-3,5-bis((triisopropylsilyl)ethynyl)benzoate

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Technology Process of methyl 4-(8-quinolinylcarbamoyl)-3,5-bis((triisopropylsilyl)ethynyl)benzoate

There total 4 articles about methyl 4-(8-quinolinylcarbamoyl)-3,5-bis((triisopropylsilyl)ethynyl)benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 878687-85-5
methyl 4-(quinolin-8-ylcarbamoyl)benzoate

: 111409-79-1
1-bromo-2-(triisopropylsilyl)acetylene

: 1351067-12-3
methyl 4-(8-quinolinylcarbamoyl)-3,5-bis((triisopropylsilyl)ethynyl)benzoate

Guidance literature:: With cesium acetate; palladium diacetate; In toluene; at 110 ℃; for 15h; regioselective reaction; Inert atmosphere;
DOI:10.1021/ol203100u

Reference yield:

: 89343-06-6
tris-iso-propylsilyl acetylene

: 1351067-12-3
methyl 4-(8-quinolinylcarbamoyl)-3,5-bis((triisopropylsilyl)ethynyl)benzoate

Guidance literature:: Multi-step reaction with 2 steps

1: N-Bromosuccinimide; silver nitrate

2: cesium acetate; palladium diacetate / toluene / 15 h / 110 °C / Inert atmosphere

With N-Bromosuccinimide; cesium acetate; palladium diacetate; silver nitrate; In toluene;
DOI:10.1021/ol203100u

Reference yield:

: 1679-64-7
Monomethyl terephthalate

: 1351067-12-3
methyl 4-(8-quinolinylcarbamoyl)-3,5-bis((triisopropylsilyl)ethynyl)benzoate

Guidance literature:: Multi-step reaction with 3 steps

1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 5 h / 0 - 20 °C / Inert atmosphere

2: triethylamine / dichloromethane / 0 - 20 °C / Inert atmosphere

3: cesium acetate; palladium diacetate / toluene / 15 h / 110 °C / Inert atmosphere

With oxalyl dichloride; cesium acetate; palladium diacetate; triethylamine; N,N-dimethyl-formamide; In dichloromethane; toluene;
DOI:10.1021/ol203100u