2-N-Acetyl-6-O-((4-nitrophenyl)ethyl)-9-(2,5-di-O-trityl-3.deoxy-3 fluoro-β-D-ribofuranosyl)guanine

Base Information

Chemical Name:2-N-Acetyl-6-O-((4-nitrophenyl)ethyl)-9-(2,5-di-O-trityl-3.deoxy-3 fluoro-β-D-ribofuranosyl)guanine
CAS No.:144588-25-0
Molecular Formula:C₅₈H₄₉FN₆O₇
Molecular Weight:961.061
Hs Code.:

Synonyms:2-N-Acetyl-6-O-((4-nitrophenyl)ethyl)-9-(2,5-di-O-trityl-3.deoxy-3 fluoro-β-D-ribofuranosyl)guanine

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Chemical Property of 2-N-Acetyl-6-O-((4-nitrophenyl)ethyl)-9-(2,5-di-O-trityl-3.deoxy-3 fluoro-β-D-ribofuranosyl)guanine

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Technology Process of 2-N-Acetyl-6-O-((4-nitrophenyl)ethyl)-9-(2,5-di-O-trityl-3.deoxy-3 fluoro-β-D-ribofuranosyl)guanine

There total 7 articles about 2-N-Acetyl-6-O-((4-nitrophenyl)ethyl)-9-(2,5-di-O-trityl-3.deoxy-3 fluoro-β-D-ribofuranosyl)guanine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 2-N-Acetyl-6-O-((4-nitrophenyl)ethyl)-9-(2,5-di-O-trityl-β-D-ribofuranosyl)guanine

: 144588-25-0
2-N-Acetyl-6-O-((4-nitrophenyl)ethyl)-9-(2,5-di-O-trityl-3.deoxy-3 fluoro-β-D-ribofuranosyl)guanine

Guidance literature:: With pyridine; 4,4'-diaminostilbene-2,2'-disulfonic acid; In dichloromethane; for 4h; Ambient temperature;
DOI:10.1021/jo00052a055

Reference yield:

: 76-83-5
trityl chloride

: 144588-25-0
2-N-Acetyl-6-O-((4-nitrophenyl)ethyl)-9-(2,5-di-O-trityl-3.deoxy-3 fluoro-β-D-ribofuranosyl)guanine

Guidance literature:: Multi-step reaction with 6 steps

1: 98 percent / 4-(dimethylamino)pyridine (DMAP) / 96 h / Ambient temperature

2: 50 percent / 2,4,6-collidine, AgNO₃ / dimethylformamide / Ambient temperature

3: 88 percent / 4-(dimethylamino)pyridine (DMAP), Et₃N / CH₂Cl₂ / 0.5 h / Ambient temperature

4: 86 percent / dimethylformamide / 1.) 3 d, 2.) 70 deg C, 5 h

5: Et₃N / methanol; H₂O / Ambient temperature

6: 76 percent / DAST, pyridine / CH₂Cl₂ / 4 h / Ambient temperature

With pyridine; 2,4,6-trimethyl-pyridine; dmap; silver nitrate; triethylamine; 4,4'-diaminostilbene-2,2'-disulfonic acid; In methanol; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1021/jo00052a055

Reference yield:

: 2-N-Acetyl-6-O-((4-nitrophenyl)ethyl)guanosine

: 144588-25-0
2-N-Acetyl-6-O-((4-nitrophenyl)ethyl)-9-(2,5-di-O-trityl-3.deoxy-3 fluoro-β-D-ribofuranosyl)guanine

Guidance literature:: Multi-step reaction with 6 steps

1: 98 percent / 4-(dimethylamino)pyridine (DMAP) / 96 h / Ambient temperature

2: 50 percent / 2,4,6-collidine, AgNO₃ / dimethylformamide / Ambient temperature

3: 88 percent / 4-(dimethylamino)pyridine (DMAP), Et₃N / CH₂Cl₂ / 0.5 h / Ambient temperature

4: 86 percent / dimethylformamide / 1.) 3 d, 2.) 70 deg C, 5 h

5: Et₃N / methanol; H₂O / Ambient temperature

6: 76 percent / DAST, pyridine / CH₂Cl₂ / 4 h / Ambient temperature

With pyridine; 2,4,6-trimethyl-pyridine; dmap; silver nitrate; triethylamine; 4,4'-diaminostilbene-2,2'-disulfonic acid; In methanol; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1021/jo00052a055