Technology Process of 4-((3-(2-carboxyethyl)-4-formyl-5-hydroxy-6-methylpyridin-2-yl)diazenyl)benzoic acid
There total 9 articles about 4-((3-(2-carboxyethyl)-4-formyl-5-hydroxy-6-methylpyridin-2-yl)diazenyl)benzoic acid which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
4-amino-benzoic acid;
With
hydrogenchloride; sodium carbonate; sodium nitrite;
In
water;
at 0 ℃;
3-(4-formyl-5-hydroxy-6-methylpyridin-3-yl)propanoic acid;
With
sodium hydroxide;
In
water;
at 0 - 25 ℃;
for 1h;
pH=10 - 11;
DOI:10.1016/j.bmc.2013.01.073
- Guidance literature:
-
With
hydrogenchloride; sodium carbonate; sodium nitrite;
In
water;
at 0 ℃;
With
sodium hydroxide;
In
water;
pH=10 - 11;
- Guidance literature:
-
Multi-step reaction with 8 steps
1.1: toluene-4-sulfonic acid / 30 h / 20 °C
2.1: dipyridinium dichromate / dichloromethane
3.1: sodium hydride / tetrahydrofuran / 0.08 h
3.2: 1 h
4.1: formic acid; water / 2 h / Reflux
5.1: palladium on activated charcoal; hydrogen / dichloromethane / 4 h
6.1: manganese(IV) oxide / dichloromethane / 2 h / 20 °C / Inert atmosphere
7.1: potassium hydroxide / methanol / 1 h
8.1: hydrogenchloride; sodium nitrite; sodium carbonate / water / 0 °C
8.2: 1 h / 0 - 25 °C / pH 10 - 11
With
hydrogenchloride; manganese(IV) oxide; dipyridinium dichromate; formic acid; palladium on activated charcoal; water; hydrogen; sodium hydride; sodium carbonate; toluene-4-sulfonic acid; potassium hydroxide; sodium nitrite;
In
tetrahydrofuran; methanol; dichloromethane; water;
3.2: |Horner-Wadsworth-Emmons Olefination;
DOI:10.1016/j.bmc.2013.01.073
