4-((3-(2-carboxyethyl)-4-formyl-5-hydroxy-6-methylpyridin-2-yl)diazenyl)benzoic acid

Base Information

Chemical Name:4-((3-(2-carboxyethyl)-4-formyl-5-hydroxy-6-methylpyridin-2-yl)diazenyl)benzoic acid
CAS No.:1345962-44-8
Molecular Formula:C₁₇H₁₅N₃O₆
Molecular Weight:357.323
Hs Code.:

Synonyms:4-((3-(2-carboxyethyl)-4-formyl-5-hydroxy-6-methylpyridin-2-yl)diazenyl)benzoic acid

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Chemical Property of 4-((3-(2-carboxyethyl)-4-formyl-5-hydroxy-6-methylpyridin-2-yl)diazenyl)benzoic acid

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Technology Process of 4-((3-(2-carboxyethyl)-4-formyl-5-hydroxy-6-methylpyridin-2-yl)diazenyl)benzoic acid

There total 9 articles about 4-((3-(2-carboxyethyl)-4-formyl-5-hydroxy-6-methylpyridin-2-yl)diazenyl)benzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 32.5%

: 150-13-0,159246-81-8,8014-65-1
4-amino-benzoic acid

: 16133-22-5
3-(4-formyl-5-hydroxy-6-methylpyridin-3-yl)propanoic acid

: 1345962-44-8
4-((3-(2-carboxyethyl)-4-formyl-5-hydroxy-6-methylpyridin-2-yl)diazenyl)benzoic acid

Guidance literature:: 4-amino-benzoic acid; With hydrogenchloride; sodium carbonate; sodium nitrite; In water; at 0 ℃;

3-(4-formyl-5-hydroxy-6-methylpyridin-3-yl)propanoic acid; With sodium hydroxide; In water; at 0 - 25 ℃; for 1h; pH=10 - 11;
DOI:10.1016/j.bmc.2013.01.073

Reference yield: 32.5%

: 1345962-44-8
4-((3-(2-carboxyethyl)-4-formyl-5-hydroxy-6-methylpyridin-2-yl)diazenyl)benzoic acid

Guidance literature:: With hydrogenchloride; sodium carbonate; sodium nitrite; In water; at 0 ℃;

With sodium hydroxide; In water; pH=10 - 11;

Reference yield:

: 65-23-6
5-hydroxy-6-methyl-3,4-pyridinedimethanol

: 1345962-44-8
4-((3-(2-carboxyethyl)-4-formyl-5-hydroxy-6-methylpyridin-2-yl)diazenyl)benzoic acid

Guidance literature:: Multi-step reaction with 8 steps

1.1: toluene-4-sulfonic acid / 30 h / 20 °C

2.1: dipyridinium dichromate / dichloromethane

3.1: sodium hydride / tetrahydrofuran / 0.08 h

3.2: 1 h

4.1: formic acid; water / 2 h / Reflux

5.1: palladium on activated charcoal; hydrogen / dichloromethane / 4 h

6.1: manganese(IV) oxide / dichloromethane / 2 h / 20 °C / Inert atmosphere

7.1: potassium hydroxide / methanol / 1 h

8.1: hydrogenchloride; sodium nitrite; sodium carbonate / water / 0 °C

8.2: 1 h / 0 - 25 °C / pH 10 - 11

With hydrogenchloride; manganese(IV) oxide; dipyridinium dichromate; formic acid; palladium on activated charcoal; water; hydrogen; sodium hydride; sodium carbonate; toluene-4-sulfonic acid; potassium hydroxide; sodium nitrite; In tetrahydrofuran; methanol; dichloromethane; water; 3.2: |Horner-Wadsworth-Emmons Olefination;
DOI:10.1016/j.bmc.2013.01.073