Methotrexate

Base Information

Chemical Name:Methotrexate
CAS No.:91431-42-4
Molecular Formula:C₁₆H₁₅ClO₆
Molecular Weight:338.745
Hs Code.:
Mol file:91431-42-4.mol

Synonyms:1,4-Naphthalenediol,6-chloro-2,3-dimethoxy-, diacetate (9CI); 6-Chloro-1,4-diacetoxy-2,3-dimethoxynaphthalene;Lonapalene; RS 43179

Suppliers and Price of Methotrexate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

ChemScene
Lonapalene 99.07%
1mg
$ 220.00

ChemScene
Lonapalene 99.07%
5mg
$ 650.00

American Custom Chemicals Corporation
LONAPALENE 95.00%
5MG
$ 503.90

Total 3 raw suppliers

Chemical Property of Methotrexate

Chemical Property:

Vapor Pressure:2E-07mmHg at 25°C
Melting Point:93-94° (Jones); mp 87.5-89.5° (Perri, Moore)
Boiling Point:424.9°Cat760mmHg
Flash Point:159.3°C
PSA：71.06000
Density:1.309g/cm³
LogP:3.36100

Purity/Quality:

99.90% ^*data from raw suppliers

Lonapalene 99.07% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of Methotrexate

There total 11 articles about Methotrexate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

: 108-24-7
acetic anhydride

: 102632-27-9
6-chloro-2,3-dimethoxynaphthalene-1,4-diol

: 91431-42-4
lonapalene

Guidance literature:: In pyridine; for 5h;
DOI:10.1016/S0040-4039(00)85136-9

Reference yield:

: 106-39-8
bromochlorobenzene

: 91431-42-4
lonapalene

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) n-BuLi / 1.) THF, -78 deg C, 20 min, 2.) 15 min

2: xylene / 2 h / Heating

3: 1.) H₂, 2.) pyridine, DMAP / 1.) 10percent Pd/C / 1.) p-xylene, 2.) overnight

With pyridine; dmap; n-butyllithium; hydrogen; palladium on activated charcoal; In xylene;
DOI:10.1021/jo00240a011

Reference yield:

: 112597-43-0
4-(4-chlorophenyl)-4-hydroxy-2,3-dimethoxycyclobut-2-enone

: 91431-42-4
lonapalene

Guidance literature:: Multi-step reaction with 2 steps

1: xylene / 2 h / Heating

2: 1.) H₂, 2.) pyridine, DMAP / 1.) 10percent Pd/C / 1.) p-xylene, 2.) overnight

With pyridine; dmap; hydrogen; palladium on activated charcoal; In xylene;
DOI:10.1021/jo00240a011