6-<<(dimethyl-tert-butylsilyl)oxy>methyl>-1-hydroxy-6-methylcyclohexene 1-triflate

Base Information

Chemical Name:6-<<(dimethyl-tert-butylsilyl)oxy>methyl>-1-hydroxy-6-methylcyclohexene 1-triflate
CAS No.:127665-57-0
Molecular Formula:C₁₅H₂₇F₃O₄SSi
Molecular Weight:388.524
Hs Code.:

Synonyms:6-<<(dimethyl-tert-butylsilyl)oxy>methyl>-1-hydroxy-6-methylcyclohexene 1-triflate

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Chemical Property of 6-<<(dimethyl-tert-butylsilyl)oxy>methyl>-1-hydroxy-6-methylcyclohexene 1-triflate

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Technology Process of 6-<<(dimethyl-tert-butylsilyl)oxy>methyl>-1-hydroxy-6-methylcyclohexene 1-triflate

There total 4 articles about 6-<<(dimethyl-tert-butylsilyl)oxy>methyl>-1-hydroxy-6-methylcyclohexene 1-triflate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 7500-91-6
methyl 2-methyl-1-oxocyclohexane-2-carboxylate

: 127665-57-0
6-<<(dimethyl-tert-butylsilyl)oxy>methyl>-1-hydroxy-6-methylcyclohexene 1-triflate

Guidance literature:: Multi-step reaction with 4 steps

1: 97 percent / LiAlH₄ / tetrahydrofuran / 1 h / Heating

2: 76 percent / NEt₃, DMAP / CH₂Cl₂ / 12 h / Ambient temperature

3: 88 percent / pyridinium dichromate / CH₂Cl₂ / 16 h

4: 1) LDA / 1) THF, -78 deg C, 2h, 2a) 0 deg C, 3h, 2b) RT, overnight

With dmap; lithium aluminium tetrahydride; dipyridinium dichromate; triethylamine; lithium diisopropyl amide; In tetrahydrofuran; dichloromethane;
DOI:10.1021/jo00304a008

Reference yield:

: 90414-70-3
2-hydroxymethyl-2-methyl-cyclohexanol

: 127665-57-0
6-<<(dimethyl-tert-butylsilyl)oxy>methyl>-1-hydroxy-6-methylcyclohexene 1-triflate

Guidance literature:: Multi-step reaction with 3 steps

1: 76 percent / NEt₃, DMAP / CH₂Cl₂ / 12 h / Ambient temperature

2: 88 percent / pyridinium dichromate / CH₂Cl₂ / 16 h

3: 1) LDA / 1) THF, -78 deg C, 2h, 2a) 0 deg C, 3h, 2b) RT, overnight

With dmap; dipyridinium dichromate; triethylamine; lithium diisopropyl amide; In dichloromethane;
DOI:10.1021/jo00304a008

Reference yield:

: 127665-55-8,127665-67-2
2-<<(dimethyl-tert-butylsilyl)oxy>methyl>-2-methylcyclohexanol

: 127665-57-0
6-<<(dimethyl-tert-butylsilyl)oxy>methyl>-1-hydroxy-6-methylcyclohexene 1-triflate

Guidance literature:: Multi-step reaction with 2 steps

1: 88 percent / pyridinium dichromate / CH₂Cl₂ / 16 h

2: 1) LDA / 1) THF, -78 deg C, 2h, 2a) 0 deg C, 3h, 2b) RT, overnight

With dipyridinium dichromate; lithium diisopropyl amide; In dichloromethane;
DOI:10.1021/jo00304a008