1-(2-methoxy-phenyl)-4-methyl-2,3-dihydro-phosphole 1-oxide

Base Information

• Chemical Name: 1-(2-methoxy-phenyl)-4-methyl-2,3-dihydro-phosphole 1-oxide
• CAS No.: 432522-13-9
• Molecular Formula: C₁₂H₁₅O₂P
• Molecular Weight: 222.224
• Mol file: 432522-13-9.mol

Synonyms:1-(2-methoxy-phenyl)-4-methyl-2,3-dihydro-phosphole 1-oxide

Chemical Property of 1-(2-methoxy-phenyl)-4-methyl-2,3-dihydro-phosphole 1-oxide

Chemical Property:

Purity/Quality:

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MSDS Files:

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Technology Process of 1-(2-methoxy-phenyl)-4-methyl-2,3-dihydro-phosphole 1-oxide

There total 2 articles about 1-(2-methoxy-phenyl)-4-methyl-2,3-dihydro-phosphole 1-oxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

2-methoxyphenylmagnesium bromide (16750-63-3) + 1-chloro-3-methyl-2-phospholene 1-oxide (823-14-3) → 1-(2-methoxy-phenyl)-4-methyl-2,3-dihydro-phosphole 1-oxide (432522-13-9)

Guidance literature:

In tetrahydrofuran; at 20 ℃; for 6h;

DOI:10.1002/jhet.5570390109 DOI:10.1080/10426500212255

Reference yield:

1-methoxy-3-methyl-2-phospholene 1-oxide (695-60-3) → 1-(2-methoxy-phenyl)-4-methyl-2,3-dihydro-phosphole 1-oxide (432522-13-9)

Guidance literature:

Multi-step reaction with 2 steps

1: SOCl₂ / 24 h / 20 °C

2: 66 percent / tetrahydrofuran / 6 h / 20 °C

With thionyl chloride; In tetrahydrofuran;

DOI:10.1002/jhet.5570390109

Reference yield: 70.0%

1-(2-methoxy-phenyl)-4-methyl-2,3-dihydro-phosphole 1-oxide (432522-13-9) → 1-(2-methoxy-3,5-dinitro-phenyl)-4-methyl-2,3-dihydro-phosphole 1-oxide

Guidance literature:

With sulfuric acid; nitric acid; at 0 - 20 ℃; for 24h;

DOI:10.1002/jhet.5570390109

upstream raw materials:

2-methoxyphenylmagnesium bromide

1-chloro-3-methyl-2-phospholene 1-oxide

1-methoxy-3-methyl-2-phospholene 1-oxide