{(S)-2-(9H-Fluoren-9-ylmethoxycarbonylamino)-6-[2-((2R,3S,4R,5S,6R)-3,4,5-triacetoxy-6-acetoxymethyl-tetrahydro-pyran-2-yl)-acetylamino]-hexanoylamino}-acetic acid benzyl ester

Base Information

• Chemical Name: {(S)-2-(9H-Fluoren-9-ylmethoxycarbonylamino)-6-[2-((2R,3S,4R,5S,6R)-3,4,5-triacetoxy-6-acetoxymethyl-tetrahydro-pyran-2-yl)-acetylamino]-hexanoylamino}-acetic acid benzyl ester
• CAS No.: 193156-82-0
• Molecular Formula: C₄₆H₅₃N₃O₁₅
• Molecular Weight: 887.938
• Mol file: 193156-82-0.mol

Synonyms:{(S)-2-(9H-Fluoren-9-ylmethoxycarbonylamino)-6-[2-((2R,3S,4R,5S,6R)-3,4,5-triacetoxy-6-acetoxymethyl-tetrahydro-pyran-2-yl)-acetylamino]-hexanoylamino}-acetic acid benzyl ester

Chemical Property of {(S)-2-(9H-Fluoren-9-ylmethoxycarbonylamino)-6-[2-((2R,3S,4R,5S,6R)-3,4,5-triacetoxy-6-acetoxymethyl-tetrahydro-pyran-2-yl)-acetylamino]-hexanoylamino}-acetic acid benzyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of {(S)-2-(9H-Fluoren-9-ylmethoxycarbonylamino)-6-[2-((2R,3S,4R,5S,6R)-3,4,5-triacetoxy-6-acetoxymethyl-tetrahydro-pyran-2-yl)-acetylamino]-hexanoylamino}-acetic acid benzyl ester

There total 6 articles about {(S)-2-(9H-Fluoren-9-ylmethoxycarbonylamino)-6-[2-((2R,3S,4R,5S,6R)-3,4,5-triacetoxy-6-acetoxymethyl-tetrahydro-pyran-2-yl)-acetylamino]-hexanoylamino}-acetic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

2-(2,3,4,6-tetra-O-acetylated-1-deoxy-α-D-galactopyranosyl)-ethanoic acid (193156-89-7) + [(S)-6-Amino-2-(9H-fluoren-9-ylmethoxycarbonylamino)-hexanoylamino]-acetic acid benzyl ester (193156-87-5) → {(S)-2-(9H-Fluoren-9-ylmethoxycarbonylamino)-6-[2-((2R,3S,4R,5S,6R)-3,4,5-triacetoxy-6-acetoxymethyl-tetrahydro-pyran-2-yl)-acetylamino]-hexanoylamino}-acetic acid benzyl ester (193156-82-0)

Guidance literature:

With benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide; In dichloromethane;

DOI:10.1016/S0960-894X(97)00255-2

Reference yield:

Fmoc-Lys(tert-butoxycarbonyl) (71989-26-9) → {(S)-2-(9H-Fluoren-9-ylmethoxycarbonylamino)-6-[2-((2R,3S,4R,5S,6R)-3,4,5-triacetoxy-6-acetoxymethyl-tetrahydro-pyran-2-yl)-acetylamino]-hexanoylamino}-acetic acid benzyl ester (193156-82-0)

Guidance literature:

Multi-step reaction with 3 steps

1: 92 percent / DCC, HOBt, DIEA / CH₂Cl₂

2: 95 percent / CF₃COOH / CH₂Cl₂

3: 87 percent / DCC, HOBt, DIEA / CH₂Cl₂

With benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide; trifluoroacetic acid; In dichloromethane;

DOI:10.1016/S0960-894X(97)00255-2

Reference yield:

allyl 2,3,4,6-tetra-O-acetyl-α-D-galactopyranoside (53263-18-6,82659-53-8,98920-46-8,98920-48-0,98920-49-1,103773-87-1,98920-44-6) → {(S)-2-(9H-Fluoren-9-ylmethoxycarbonylamino)-6-[2-((2R,3S,4R,5S,6R)-3,4,5-triacetoxy-6-acetoxymethyl-tetrahydro-pyran-2-yl)-acetylamino]-hexanoylamino}-acetic acid benzyl ester (193156-82-0)

Guidance literature:

Multi-step reaction with 3 steps

1: 1.) O₃, 2.) Zn, AcOH / 1.) CH₂Cl₂, -78 deg C, 2.) 0 deg C

2: 95 percent / KMnO₄, NaH₂PO₄ / 2-methyl-propan-2-ol

3: 87 percent / DCC, HOBt, DIEA / CH₂Cl₂

With potassium permanganate; sodium dihydrogenphosphate; benzotriazol-1-ol; ozone; acetic acid; N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide; zinc; In dichloromethane; tert-butyl alcohol;

DOI:10.1016/S0960-894X(97)00255-2

upstream raw materials:

2-(2,3,4,6-tetra-O-acetylated-1-deoxy-α-D-galactopyranosyl)-ethanoic acid

[(S)-6-Amino-2-(9H-fluoren-9-ylmethoxycarbonylamino)-hexanoylamino]-acetic acid benzyl ester

Fmoc-Lys(tert-butoxycarbonyl)

allyl 2,3,4,6-tetra-O-acetyl-α-D-galactopyranoside

Downstream raw materials:

{(S)-2-(9H-Fluoren-9-ylmethoxycarbonylamino)-6-[2-((2R,3S,4R,5S,6R)-3,4,5-triacetoxy-6-acetoxymethyl-tetrahydro-pyran-2-yl)-ethylamino]-hexanoylamino}-acetic acid benzyl ester