(4S,5S)-N-isopentyl-5-<<(tert-butyloxy)carbonyl>amino>-6-cyclohexyl-4-hydroxyhex-1-ene-2-carboxamide

Base Information

Chemical Name:(4S,5S)-N-isopentyl-5-<<(tert-butyloxy)carbonyl>amino>-6-cyclohexyl-4-hydroxyhex-1-ene-2-carboxamide
CAS No.:110613-67-7
Molecular Formula:C₂₃H₄₂N₂O₄
Molecular Weight:410.597
Hs Code.:

Synonyms:(4S,5S)-N-isopentyl-5-<<(tert-butyloxy)carbonyl>amino>-6-cyclohexyl-4-hydroxyhex-1-ene-2-carboxamide

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Chemical Property of (4S,5S)-N-isopentyl-5-<<(tert-butyloxy)carbonyl>amino>-6-cyclohexyl-4-hydroxyhex-1-ene-2-carboxamide

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Technology Process of (4S,5S)-N-isopentyl-5-<<(tert-butyloxy)carbonyl>amino>-6-cyclohexyl-4-hydroxyhex-1-ene-2-carboxamide

There total 1 articles about (4S,5S)-N-isopentyl-5-<<(tert-butyloxy)carbonyl>amino>-6-cyclohexyl-4-hydroxyhex-1-ene-2-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 98105-42-1
(S)-2-(t-butoxycarbonylamino)-3-cyclohexyl-1-propanal

: 110613-29-1
N-isopentylmethacrylamide

: 110613-75-7
(4R,5S)-N-isopentyl-5-<<(tert-butyloxy)carbonyl>amino>-6-cyclohexyl-4-hydroxyhex-1-ene-2-carboxamide

: 110613-67-7
(4S,5S)-N-isopentyl-5-<<(tert-butyloxy)carbonyl>amino>-6-cyclohexyl-4-hydroxyhex-1-ene-2-carboxamide

Guidance literature:: With triisopropoxytitanium(IV) chloride; n-butyllithium; Yield given. Multistep reaction. Yields of byproduct given;
DOI:10.1021/jm00394a008

Reference yield:

: 110613-67-7
(4S,5S)-N-isopentyl-5-<<(tert-butyloxy)carbonyl>amino>-6-cyclohexyl-4-hydroxyhex-1-ene-2-carboxamide

: 110613-62-2,110660-42-9
{(S)-1-[(S)-1-[(1S,2S,4R)-1-Cyclohexylmethyl-2,4-dihydroxy-4-(3-methyl-butylcarbamoyl)-pentylcarbamoyl]-2-(1H-imidazol-4-yl)-ethylcarbamoyl]-2-phenyl-ethyl}-carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 3-chloroperoxybenzoic acid / CH₂Cl₂ / 18 h / Ambient temperature

2: 68 percent / H₂ / 20percent Pd/C / methanol / 12 h

3: HCl(g) / dioxane / 1 h / Ambient temperature

4: 1-hydroxybenzotriazole*H₂O, 4-methylmorpholine, 1-ethyl-3-<3-(dimethylamino)propyl>carbodiimide*HCl / dimethylformamide / -23 - 20 °C

With 4-methyl-morpholine; hydrogenchloride; hydrogen; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; 3-chloro-benzenecarboperoxoic acid; palladium on activated charcoal; In 1,4-dioxane; methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm00394a008

Reference yield:

: 110613-67-7
(4S,5S)-N-isopentyl-5-<<(tert-butyloxy)carbonyl>amino>-6-cyclohexyl-4-hydroxyhex-1-ene-2-carboxamide

: 110613-62-2,110660-42-9
{(S)-1-[(S)-1-[(1S,2S,4S)-1-Cyclohexylmethyl-2,4-dihydroxy-4-(3-methyl-butylcarbamoyl)-pentylcarbamoyl]-2-(1H-imidazol-4-yl)-ethylcarbamoyl]-2-phenyl-ethyl}-carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 3-chloroperoxybenzoic acid / CH₂Cl₂ / 18 h / Ambient temperature

2: 62 percent / H₂ / 20percent Pd/C / methanol / 12 h

3: HCl(g) / dioxane / 1 h / Ambient temperature

4: 1-hydroxybenzotriazole*H₂O, 4-methylmorpholine, 1-ethyl-3-<3-(dimethylamino)propyl>carbodiimide*HCl / dimethylformamide / -23 - 20 °C

With 4-methyl-morpholine; hydrogenchloride; hydrogen; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; 3-chloro-benzenecarboperoxoic acid; palladium on activated charcoal; In 1,4-dioxane; methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm00394a008