3-O-benzyl-N-benzyloxycarbonyl-1,4,5-trideoxy-1,5-imino-D-threo-pentitol

Base Information

Chemical Name:3-O-benzyl-N-benzyloxycarbonyl-1,4,5-trideoxy-1,5-imino-D-threo-pentitol
CAS No.:266688-42-0
Molecular Formula:C₂₀H₂₁NO₅
Molecular Weight:355.39
Hs Code.:

Synonyms:3-O-benzyl-N-benzyloxycarbonyl-1,4,5-trideoxy-1,5-imino-D-threo-pentitol

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Chemical Property of 3-O-benzyl-N-benzyloxycarbonyl-1,4,5-trideoxy-1,5-imino-D-threo-pentitol

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Technology Process of 3-O-benzyl-N-benzyloxycarbonyl-1,4,5-trideoxy-1,5-imino-D-threo-pentitol

There total 8 articles about 3-O-benzyl-N-benzyloxycarbonyl-1,4,5-trideoxy-1,5-imino-D-threo-pentitol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 44.0%

: 54769-36-7
N-benzoyloxybenzotriazole

: 266688-41-9,167096-99-3,167097-00-9
(3R,4R)-(+)-trans-1-benzyloxycarbonyl-3,4-dihydroxypiperidine

: 266688-42-0
3-O-benzyl-N-benzyloxycarbonyl-1,4,5-trideoxy-1,5-imino-D-threo-pentitol

: 266688-43-1
2-O-benzyl-N-benzyloxycarbonyl-1,4,5-trideoxy-1,5-imino-D-threo-pentitol

Guidance literature:: With triethylamine; In dichloromethane; at 20 ℃;
DOI:10.1021/ja993805j

Reference yield:

: 266688-37-3
methyl 4-cyano-4-deoxy-D-threonate

: 266688-42-0
3-O-benzyl-N-benzyloxycarbonyl-1,4,5-trideoxy-1,5-imino-D-threo-pentitol

Guidance literature:: Multi-step reaction with 8 steps

1: pyridine / 1 h / 20 °C

2: 64 percent / H₂ / PtO₂ / methanol

3: 90 percent / Na; MeOH / 2 h / 20 °C

4: trimethylsilyl chloride / acetonitrile / 2 h / Heating

5: BH₃*Me₂S / dioxane / 2 h / Heating

6: 1M aq. HCl / 1 h / Heating

7: saturated aq. NaHCO₃

8: 44 percent / Et₃N / CH₂Cl₂ / 20 °C

With pyridine; hydrogenchloride; methanol; chloro-trimethyl-silane; dimethylsulfide borane complex; hydrogen; sodium; sodium hydrogencarbonate; triethylamine; platinum(IV) oxide; In 1,4-dioxane; methanol; dichloromethane; acetonitrile; 1: Acetylation / 2: Catalytic hydrogenation / 3: Deacetylation / 4: silylation / 5: Reduction / 6: desilylation / 7: Carboxylation / 8: Acylation;
DOI:10.1021/ja993805j

Reference yield:

: 266688-38-4
methyl 2,3-di-O-acetyl-4-cyano-4-deoxy-D-threonate

: 266688-42-0
3-O-benzyl-N-benzyloxycarbonyl-1,4,5-trideoxy-1,5-imino-D-threo-pentitol

Guidance literature:: Multi-step reaction with 7 steps

1: 64 percent / H₂ / PtO₂ / methanol

2: 90 percent / Na; MeOH / 2 h / 20 °C

3: trimethylsilyl chloride / acetonitrile / 2 h / Heating

4: BH₃*Me₂S / dioxane / 2 h / Heating

5: 1M aq. HCl / 1 h / Heating

6: saturated aq. NaHCO₃

7: 44 percent / Et₃N / CH₂Cl₂ / 20 °C

With hydrogenchloride; methanol; chloro-trimethyl-silane; dimethylsulfide borane complex; hydrogen; sodium; sodium hydrogencarbonate; triethylamine; platinum(IV) oxide; In 1,4-dioxane; methanol; dichloromethane; acetonitrile; 1: Catalytic hydrogenation / 2: Deacetylation / 3: silylation / 4: Reduction / 5: desilylation / 6: Carboxylation / 7: Acylation;
DOI:10.1021/ja993805j