5-Fluoro-2-thio-2'-deoxyuridylate

Base Information

Chemical Name:5-Fluoro-2-thio-2'-deoxyuridylate
CAS No.:151134-50-8
Molecular Formula:C₉H₁₂FN₂O₇PS
Molecular Weight:342.242
Hs Code.:
DSSTox Substance ID:DTXSID40164716
Nikkaji Number:J2.025.422J
Wikidata:Q83033793
Mol file:151134-50-8.mol

Synonyms:2-thio-5-fluoro-dUMP;2-thio-FdUMP;5-fluoro-2-thio-2'-deoxyuridine 5'-monophosphate;5-fluoro-2-thio-2'-deoxyuridylate;5-fluoro-2-thio-dUMP

Suppliers and Price of 5-Fluoro-2-thio-2'-deoxyuridylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 1 raw suppliers

Chemical Property of 5-Fluoro-2-thio-2'-deoxyuridylate

Chemical Property:

Boiling Point:°Cat760mmHg
Flash Point:°C
PSA：176.17000
Density:1.82g/cm³
LogP:0.21500
XLogP3:-2.2
Hydrogen Bond Donor Count:4
Hydrogen Bond Acceptor Count:9
Rotatable Bond Count:4
Exact Mass:342.00868706
Heavy Atom Count:21
Complexity:538

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1C(C(OC1N2C=C(C(=O)NC2=S)F)COP(=O)(O)O)O
Isomeric SMILES:C1[C@@H]([C@H](O[C@H]1N2C=C(C(=O)NC2=S)F)COP(=O)(O)O)O

Technology Process of 5-Fluoro-2-thio-2'-deoxyuridylate

There total 4 articles about 5-Fluoro-2-thio-2'-deoxyuridylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 48.0%

: 2'-deoxy-5-fluoro-2-thiouridine

: 151134-50-8
2'-deoxy-5-fluoro-2-thiouridine 5'-phosphate

Guidance literature:: With acetate buffer; tris(p-nitrophenyl)phosphate; acetic acid; at 37 ℃; for 40h; wheat shoot nucleoside phosphotransferase;
DOI:10.1021/jm00075a016

Reference yield: 24.0%

: α-2'-deoxy-5-fluoro-2-thiouridine

: 151134-50-8
α-2'-deoxy-5-fluoro-2-thiouridine 5'-phosphate

Guidance literature:: With acetate buffer; tris(p-nitrophenyl)phosphate; acetic acid; at 37 ℃; for 40h; wheat shoot nucleoside phosphotransferase;
DOI:10.1021/jm00075a016

Reference yield:

: 152310-73-1
1-(2-deoxy-3,5-di-O-p-toluyl-β-D-ribofuranosyl)-5-fluoro-2-thiouracil

: 151134-50-8
2'-deoxy-5-fluoro-2-thiouridine 5'-phosphate

Guidance literature:: Multi-step reaction with 2 steps

1: 66 percent / methanolic NH₃ / Ambient temperature

2: 48 percent / p-nitrophenyl phosphate, acetate buffer, acetic acid / 40 h / 37 °C / wheat shoot nucleoside phosphotransferase

With acetate buffer; tris(p-nitrophenyl)phosphate; ammonia; acetic acid;
DOI:10.1021/jm00075a016