(-)-2-(4-fluorophenyl)-1-(11-methyl-5,6,7,8,9,10-hexahydro-7,10-iminocyclohept[b]indol-5-yl)propan-2-ol

Base Information

• Chemical Name: (-)-2-(4-fluorophenyl)-1-(11-methyl-5,6,7,8,9,10-hexahydro-7,10-iminocyclohept[b]indol-5-yl)propan-2-ol
• CAS No.: 1189784-64-2
• Molecular Formula: C₂₃H₂₅FN₂O
• Molecular Weight: 364.463
• Mol file: 1189784-64-2.mol

Synonyms:(-)-2-(4-fluorophenyl)-1-(11-methyl-5,6,7,8,9,10-hexahydro-7,10-iminocyclohept[b]indol-5-yl)propan-2-ol

Chemical Property of (-)-2-(4-fluorophenyl)-1-(11-methyl-5,6,7,8,9,10-hexahydro-7,10-iminocyclohept[b]indol-5-yl)propan-2-ol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (-)-2-(4-fluorophenyl)-1-(11-methyl-5,6,7,8,9,10-hexahydro-7,10-iminocyclohept[b]indol-5-yl)propan-2-ol

There total 1 articles about (-)-2-(4-fluorophenyl)-1-(11-methyl-5,6,7,8,9,10-hexahydro-7,10-iminocyclohept[b]indol-5-yl)propan-2-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(-)-11-methyl-5,6,7,8,9,10-hexahydro-7,10-iminocyclohept[b]indole (1189785-27-0) + p-fluoro-α-methylstyrene oxide (2967-83-1,235096-15-8) → (-)-2-(4-fluorophenyl)-1-(11-methyl-5,6,7,8,9,10-hexahydro-7,10-iminocyclohept[b]indol-5-yl)propan-2-ol (1189784-64-2)

Guidance literature:

With sodium hydride; In N,N-dimethyl-formamide; at 20 ℃; for 14h;

Reference yield:

(-)-2-(4-fluorophenyl)-1-(11-methyl-5,6,7,8,9,10-hexahydro-7,10-iminocyclohept[b]indol-5-yl)propan-2-ol (1189784-64-2) + trifluoroacetic acid (76-05-1) → (x)C2HF3O2*C23H23FN2

Guidance literature:

(-)-2-(4-fluorophenyl)-1-(11-methyl-5,6,7,8,9,10-hexahydro-7,10-iminocyclohept[b]indol-5-yl)propan-2-ol; With sulfuric acid; In water; at 90 ℃; for 2h;

With potassium hydroxide; In water; Cooling;

trifluoroacetic acid;

Reference yield:

(-)-2-(4-fluorophenyl)-1-(11-methyl-5,6,7,8,9,10-hexahydro-7,10-iminocyclohept[b]indol-5-yl)propan-2-ol (1189784-64-2) + oxalic acid (144-62-7,97993-78-7) → (x)C2H2O4*C23H25FN2O

Guidance literature:

In tetrahydrofuran;

upstream raw materials:

(-)-11-methyl-5,6,7,8,9,10-hexahydro-7,10-iminocyclohept[b]indole

p-fluoro-α-methylstyrene oxide