(E)-S-1-methyl-2-oxo-2-phenylethyl thiocinnamate

Base Information

• Chemical Name: (E)-S-1-methyl-2-oxo-2-phenylethyl thiocinnamate
• CAS No.: 941568-95-2
• Molecular Formula: C₁₈H₁₆O₂S
• Molecular Weight: 296.39
• Mol file: 941568-95-2.mol

Synonyms:(E)-S-1-methyl-2-oxo-2-phenylethyl thiocinnamate

Chemical Property of (E)-S-1-methyl-2-oxo-2-phenylethyl thiocinnamate

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of (E)-S-1-methyl-2-oxo-2-phenylethyl thiocinnamate

There total 1 articles about (E)-S-1-methyl-2-oxo-2-phenylethyl thiocinnamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-mercapto-1-phenylpropan-1-one (13792-77-3,140237-90-7,140237-91-8) + Cinnamoyl chloride (102-92-1,17082-09-6) → (E)-S-1-methyl-2-oxo-2-phenylethyl thiocinnamate (941568-95-2)

Guidance literature:

With pyridine; dmap; In dichloromethane; at 20 ℃;

DOI:10.1021/ol0705200

Reference yield:

(E)-S-1-methyl-2-oxo-2-phenylethyl thiocinnamate (941568-95-2) + ethyl 2,2-dibromopropanoate (34757-17-0) → C20H18SH2CO3

Guidance literature:

ethyl 2,2-dibromopropanoate; With tert.-butyl lithium; In tetrahydrofuran; pentane; at -78 - 0 ℃;

(E)-S-1-methyl-2-oxo-2-phenylethyl thiocinnamate; In tetrahydrofuran; pentane; at -78 ℃; for 0.5h; Further stages.;

DOI:10.1021/ol0705200

Reference yield:

(E)-S-1-methyl-2-oxo-2-phenylethyl thiocinnamate (941568-95-2) → 2,4-dimethyl-3-phenyl-5-styrylthiophene

Guidance literature:

Multi-step reaction with 2 steps

1.1: t-BuLi / tetrahydrofuran; pentane / -78 - 0 °C

1.2: tetrahydrofuran; pentane / 0.5 h / -78 °C

2.1: xylene / Heating

With tert.-butyl lithium; In tetrahydrofuran; xylene; pentane;

DOI:10.1021/ol0705200

upstream raw materials:

2-mercapto-1-phenylpropan-1-one

Cinnamoyl chloride