N₆-{1-[4-(3-trifluoroacetamido-1-propynyl)phenyl]ethyl}-2'-deoxyadenosine

Base Information

Chemical Name:N₆-{1-[4-(3-trifluoroacetamido-1-propynyl)phenyl]ethyl}-2'-deoxyadenosine
CAS No.:1030006-41-7
Molecular Formula:C₂₃H₂₃F₃N₆O₄
Molecular Weight:504.469
Hs Code.:

N<sub>6</sub>-{1-[4-(3-trifluoroacetamido-1-propynyl)phenyl]ethyl}-2'-deoxyadenosine

Synonyms:N₆-{1-[4-(3-trifluoroacetamido-1-propynyl)phenyl]ethyl}-2'-deoxyadenosine

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Chemical Property of N₆-{1-[4-(3-trifluoroacetamido-1-propynyl)phenyl]ethyl}-2'-deoxyadenosine

Chemical Property:

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Technology Process of N₆-{1-[4-(3-trifluoroacetamido-1-propynyl)phenyl]ethyl}-2'-deoxyadenosine

There total 5 articles about N₆-{1-[4-(3-trifluoroacetamido-1-propynyl)phenyl]ethyl}-2'-deoxyadenosine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 1030006-38-2
N₆-[1-(4-iodophenyl)ethyl]-2'-deoxyadenosine

: 14719-21-2
trifluoroacetyl-propargyl amine

: 1030006-41-7
N₆-{1-[4-(3-trifluoroacetamido-1-propynyl)phenyl]ethyl}-2'-deoxyadenosine

Guidance literature:: With copper(l) iodide; triethylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In N,N-dimethyl-formamide; at 20 ℃; for 5.5h;

Reference yield:

: 106568-83-6
3′,5′-bis-O-(tert-butyldimethylsilyl)-2′-deoxyinosine

: 1030006-41-7
N₆-{1-[4-(3-trifluoroacetamido-1-propynyl)phenyl]ethyl}-2'-deoxyadenosine

Guidance literature:: Multi-step reaction with 4 steps

1: dmap; triethylamine / dichloromethane / 1.5 h / 20 °C

2: 1,4-dioxane / 18 h / 50 °C / Molecular sieve; Inert atmosphere

3: tetrabutyl ammonium fluoride / tetrahydrofuran / 0 - 20 °C

4: triethylamine; copper(l) iodide / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / 5.5 h / 20 °C

With dmap; copper(l) iodide; tetrabutyl ammonium fluoride; triethylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 1030006-35-9
N₆-[1-(4-iodophenyl)ethyl]-3',5'-bis-O-tert-butyldimethylsilyl-2'-deoxyadenosine

: 1030006-41-7
N₆-{1-[4-(3-trifluoroacetamido-1-propynyl)phenyl]ethyl}-2'-deoxyadenosine

Guidance literature:: Multi-step reaction with 2 steps

1: tetrabutyl ammonium fluoride / tetrahydrofuran / 0 - 20 °C

2: triethylamine; copper(l) iodide / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / 5.5 h / 20 °C

With copper(l) iodide; tetrabutyl ammonium fluoride; triethylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; N,N-dimethyl-formamide;