(S)-2-{4-[(S)-2-Amino-3-(2-amino-5-hydroxy-6-oxo-1,6-dihydro-pyrimidin-4-ylamino)-propylamino]-benzoylamino}-pentanedioic acid

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Chemical Name:(S)-2-{4-[(S)-2-Amino-3-(2-amino-5-hydroxy-6-oxo-1,6-dihydro-pyrimidin-4-ylamino)-propylamino]-benzoylamino}-pentanedioic acid
CAS No.:142811-42-5
Molecular Formula:C₁₉H₂₅N₇O₇
Molecular Weight:463.45
Hs Code.:

Synonyms:(S)-2-{4-[(S)-2-Amino-3-(2-amino-5-hydroxy-6-oxo-1,6-dihydro-pyrimidin-4-ylamino)-propylamino]-benzoylamino}-pentanedioic acid

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Chemical Property of (S)-2-{4-[(S)-2-Amino-3-(2-amino-5-hydroxy-6-oxo-1,6-dihydro-pyrimidin-4-ylamino)-propylamino]-benzoylamino}-pentanedioic acid

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Technology Process of (S)-2-{4-[(S)-2-Amino-3-(2-amino-5-hydroxy-6-oxo-1,6-dihydro-pyrimidin-4-ylamino)-propylamino]-benzoylamino}-pentanedioic acid

There total 6 articles about (S)-2-{4-[(S)-2-Amino-3-(2-amino-5-hydroxy-6-oxo-1,6-dihydro-pyrimidin-4-ylamino)-propylamino]-benzoylamino}-pentanedioic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 142811-51-6
N-<4-<<2(S)-amino-3-<(2,5-diamino-4(3H)-oxopyrimidin-6-yl)amino>propyl>amino>benzoyl>-L-glutamic acid

: 135-16-0,15582-28-2,29347-89-5,71963-69-4,74708-38-6
(6S,S)-5,6,7,8-tetrahydrofolic acid

: 142811-42-5
(S)-2-{4-[(S)-2-Amino-3-(2-amino-5-hydroxy-6-oxo-1,6-dihydro-pyrimidin-4-ylamino)-propylamino]-benzoylamino}-pentanedioic acid

: 31690-11-6
N⁵,N¹⁰-methylenetetrahydrofolate

: 4033-27-6
(S)-2-{4-[(2-Amino-4-oxo-3,4,7,8-tetrahydro-pteridin-6-ylmethyl)-amino]-benzoylamino}-pentanedioic acid

Guidance literature:: Multistep reaction;
DOI:10.1021/jo00042a030

Reference yield:

: 142811-46-9
2-amino-6<<2'(R)-(benzylamino)-3'-hydroxypropyl>amino>-5-nitro-4(3H)-pyrimidinone

: 142811-42-5
(S)-2-{4-[(S)-2-Amino-3-(2-amino-5-hydroxy-6-oxo-1,6-dihydro-pyrimidin-4-ylamino)-propylamino]-benzoylamino}-pentanedioic acid

Guidance literature:: Multi-step reaction with 6 steps

1: 93 percent / 1 M aq. NaOH -> pH 9.5 / dioxane / 46 h / Ambient temperature

2: 5.01 g / Dess-Martin periodinane, AcOH / CH₂Cl₂ / 1.17 h / Ambient temperature

3: 2) NaBH₃CN / 1) DMF, 0 deg C, 5 min, 2) DMF, 0 deg C, 1 h

4: 98 percent / aq. 1 M HCl / tetrahydrofuran / 2.5 h / 58 °C

5: 91 percent / hydrogen / 10percent Pd-C / dimethylformamide; aq. HCl / 25 h / 2327.2 Torr

With hydrogenchloride; sodium hydroxide; hydrogen; sodium cyanoborohydride; Dess-Martin periodane; acetic acid; palladium on activated charcoal; In tetrahydrofuran; 1,4-dioxane; hydrogenchloride; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jo00042a030

Reference yield:

: 142811-49-2
N-<4-<<2(S)--3-<(2-amino-5-nitro-4(3H)-oxopyrimidin-6-yl)amino>propyl>amino>benzoyl>-L-glutamic acid

: 142811-42-5
(S)-2-{4-[(S)-2-Amino-3-(2-amino-5-hydroxy-6-oxo-1,6-dihydro-pyrimidin-4-ylamino)-propylamino]-benzoylamino}-pentanedioic acid

Guidance literature:: Multi-step reaction with 3 steps

1: 98 percent / aq. 1 M HCl / tetrahydrofuran / 2.5 h / 58 °C

2: 91 percent / hydrogen / 10percent Pd-C / dimethylformamide; aq. HCl / 25 h / 2327.2 Torr

With hydrogenchloride; hydrogen; palladium on activated charcoal; In tetrahydrofuran; hydrogenchloride; N,N-dimethyl-formamide;
DOI:10.1021/jo00042a030