5'-O-benzyl-3'-O-(tert-butyldimethylsilyl)-2'-deoxy-4'α-methoxycarbonyl-D-thymidine

Base Information

Chemical Name:5'-O-benzyl-3'-O-(tert-butyldimethylsilyl)-2'-deoxy-4'α-methoxycarbonyl-D-thymidine
CAS No.:208175-42-2
Molecular Formula:C₂₅H₃₆N₂O₇Si
Molecular Weight:504.656
Hs Code.:

Synonyms:5'-O-benzyl-3'-O-(tert-butyldimethylsilyl)-2'-deoxy-4'α-methoxycarbonyl-D-thymidine

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Chemical Property of 5'-O-benzyl-3'-O-(tert-butyldimethylsilyl)-2'-deoxy-4'α-methoxycarbonyl-D-thymidine

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Technology Process of 5'-O-benzyl-3'-O-(tert-butyldimethylsilyl)-2'-deoxy-4'α-methoxycarbonyl-D-thymidine

There total 4 articles about 5'-O-benzyl-3'-O-(tert-butyldimethylsilyl)-2'-deoxy-4'α-methoxycarbonyl-D-thymidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: methyl 5-O-benzyl-2-deoxy-4α-methoxycarbonyl-α,β-D-ribo-pentofuranoside

: 208175-42-2
5'-O-benzyl-3'-O-(tert-butyldimethylsilyl)-2'-deoxy-4'α-methoxycarbonyl-D-thymidine

Guidance literature:: Multi-step reaction with 2 steps

1: 2,6-lutidine / CH₂Cl₂ / 1 h / Ambient temperature

2: 1.) N,O-bis(trimethyllsilyl)acetamide, 2.) SnCl₄ / 1.) MeCN, 80 deg C, 30 min, 2.) MeCN, 0 deg C -> rt

With 2,6-dimethylpyridine; N,O-bis-(trimethylsilyl)-acetamide; tin(IV) chloride; In dichloromethane;
DOI:10.1021/jo990046e

Reference yield:

: 65-71-4,28806-14-6,691841-57-3
thymin

: 484678-85-5
methyl 5-O-benzyl-3-O-(tert-butyldimethylsilyl)-2-deoxy-4α-methoxycarbonyl-α,β-D-ribo-pentofuranoside

: 208175-17-1
(2R,3S,5S)-2-Benzyloxymethyl-3-(tert-butyl-dimethyl-silanyloxy)-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-carboxylic acid methyl ester

: 208175-42-2
5'-O-benzyl-3'-O-(tert-butyldimethylsilyl)-2'-deoxy-4'α-methoxycarbonyl-D-thymidine

Guidance literature:: With tin(IV) chloride; In acetonitrile; Yield given. Yields of byproduct given;
DOI:10.1021/jo980301f

Reference yield:

: 69739-34-0
t-butyldimethylsiyl triflate

: 208175-42-2
5'-O-benzyl-3'-O-(tert-butyldimethylsilyl)-2'-deoxy-4'α-methoxycarbonyl-D-thymidine

Guidance literature:: Multi-step reaction with 2 steps

1: 2,6-lutidine / CH₂Cl₂ / 1 h / Ambient temperature

2: 1.) N,O-bis(trimethyllsilyl)acetamide, 2.) SnCl₄ / 1.) MeCN, 80 deg C, 30 min, 2.) MeCN, 0 deg C -> rt

With 2,6-dimethylpyridine; N,O-bis-(trimethylsilyl)-acetamide; tin(IV) chloride; In dichloromethane;
DOI:10.1021/jo990046e