2-(5-(5-(3-(methylsulfonyl)phenyl)furan-2-yl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)acetic acid

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Chemical Name:2-(5-(5-(3-(methylsulfonyl)phenyl)furan-2-yl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)acetic acid
CAS No.:1454288-95-9
Molecular Formula:C₁₇H₁₃F₃N₂O₅S
Molecular Weight:414.362
Hs Code.:

Synonyms:2-(5-(5-(3-(methylsulfonyl)phenyl)furan-2-yl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)acetic acid

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Chemical Property of 2-(5-(5-(3-(methylsulfonyl)phenyl)furan-2-yl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)acetic acid

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Technology Process of 2-(5-(5-(3-(methylsulfonyl)phenyl)furan-2-yl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)acetic acid

There total 6 articles about 2-(5-(5-(3-(methylsulfonyl)phenyl)furan-2-yl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 1454289-85-0
ethyl 2-(5-(5-(3-(methylsulfonyl)phenyl)furan-2-yl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)acetate

: 1454288-95-9
2-(5-(5-(3-(methylsulfonyl)phenyl)furan-2-yl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)acetic acid

Guidance literature:: With lithium hydroxide; In tetrahydrofuran; water; at 20 ℃; for 2h;

Reference yield:

: 1454290-71-1
1-(5-bromofuran-2-yl)-4,4,4-trifluorobutane-1,3-dione

: 1454288-95-9
2-(5-(5-(3-(methylsulfonyl)phenyl)furan-2-yl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)acetic acid

Guidance literature:: Multi-step reaction with 4 steps

1: Reflux

2: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / N,N-dimethyl-formamide / 3 h / 90 °C / Inert atmosphere

3: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 1.5 h / 20 °C

4: lithium hydroxide / tetrahydrofuran; water / 2 h / 20 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; 3-chloro-benzenecarboperoxoic acid; lithium hydroxide; In tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide;

Reference yield:

: 3199-50-6
1-(5-bromofuran-2-yl)ethanone

: 1454288-95-9
2-(5-(5-(3-(methylsulfonyl)phenyl)furan-2-yl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)acetic acid

Guidance literature:: Multi-step reaction with 5 steps

1.1: lithium hexamethyldisilazane / tetrahydrofuran / 1 h / -78 °C

1.2: -78 - 20 °C

2.1: Reflux

3.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / N,N-dimethyl-formamide / 3 h / 90 °C / Inert atmosphere

4.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 1.5 h / 20 °C

5.1: lithium hydroxide / tetrahydrofuran; water / 2 h / 20 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; 3-chloro-benzenecarboperoxoic acid; lithium hydroxide; lithium hexamethyldisilazane; In tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide;