(S)-2-hydroxy-6<(trifluoroacetyl)amino>hexanoic acid phenylmethyl ester

Base Information

Chemical Name:(S)-2-hydroxy-6<(trifluoroacetyl)amino>hexanoic acid phenylmethyl ester
CAS No.:107504-49-4
Molecular Formula:C₁₅H₁₈F₃NO₄
Molecular Weight:333.307
Hs Code.:

Synonyms:(S)-2-hydroxy-6<(trifluoroacetyl)amino>hexanoic acid phenylmethyl ester

Suppliers and Price of (S)-2-hydroxy-6<(trifluoroacetyl)amino>hexanoic acid phenylmethyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 1 raw suppliers

Chemical Property of (S)-2-hydroxy-6<(trifluoroacetyl)amino>hexanoic acid phenylmethyl ester

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of (S)-2-hydroxy-6<(trifluoroacetyl)amino>hexanoic acid phenylmethyl ester

There total 1 articles about (S)-2-hydroxy-6<(trifluoroacetyl)amino>hexanoic acid phenylmethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 42491-84-9
(S)-6-Amino-2-hydroxyhexanoic acid

: 107504-49-4
(S)-2-hydroxy-6<(trifluoroacetyl)amino>hexanoic acid phenylmethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) bis(trimethylsilyl)trifluoroacetamide / 1.) acetonitrile, room temp., 2 h

2: potassium carbonate / dimethylformamide / 5 h / Ambient temperature

With bis(trimethylsilyl)trifluoroacetamide; potassium carbonate; In N,N-dimethyl-formamide;
DOI:10.1021/jm00167a028

Reference yield:

: 107504-49-4
(S)-2-hydroxy-6<(trifluoroacetyl)amino>hexanoic acid phenylmethyl ester

: 126111-23-7
N-{4-[(S)-2,5-Dioxo-2-(4-phenyl-butyl)-2λ⁵-[1,3,2]dioxaphospholan-4-yl]-butyl}-2,2,2-trifluoro-acetamide

Guidance literature:: Multi-step reaction with 4 steps

1: N,N'-dicyclohexylcarbodiimide, 4-(dimethylamino)pyridine / tetrahydrofuran / 2 h / Ambient temperature

2: NaIO₄ / dioxane; H₂O / 18 h / Ambient temperature

3: H₂ / 10percent Pd/C / methanol; H₂O / 2 h / 1551.4 Torr

4: 1,1'-carbonyldiimidazole / tetrahydrofuran / 1 h / 0 °C

With dmap; sodium periodate; hydrogen; dicyclohexyl-carbodiimide; 1,1'-carbonyldiimidazole; palladium on activated charcoal; In tetrahydrofuran; 1,4-dioxane; methanol; water;
DOI:10.1021/jm00167a028

Reference yield:

: 107504-49-4
(S)-2-hydroxy-6<(trifluoroacetyl)amino>hexanoic acid phenylmethyl ester

: (2S,4S)-4-Benzyl-1-[(S)-2-[hydroxy-(4-phenyl-butyl)-phosphinoyloxy]-6-(2,2,2-trifluoro-acetylamino)-hexanoyl]-pyrrolidine-2-carboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: N,N'-dicyclohexylcarbodiimide, 4-(dimethylamino)pyridine / tetrahydrofuran / 2 h / Ambient temperature

2: NaIO₄ / dioxane; H₂O / 18 h / Ambient temperature

3: H₂ / 10percent Pd/C / methanol; H₂O / 2 h / 1551.4 Torr

4: 1,1'-carbonyldiimidazole / tetrahydrofuran / 1 h / 0 °C

5: triethylamine / tetrahydrofuran / 4.5 h / Ambient temperature

With dmap; sodium periodate; hydrogen; triethylamine; dicyclohexyl-carbodiimide; 1,1'-carbonyldiimidazole; palladium on activated charcoal; In tetrahydrofuran; 1,4-dioxane; methanol; water;
DOI:10.1021/jm00167a028