2,6-dimethyl-β-phenethylsulfonamide

Base Information

• Chemical Name: 2,6-dimethyl-β-phenethylsulfonamide
• CAS No.: 96129-76-9
• Molecular Formula: C₁₀H₁₅NO₂S
• Molecular Weight: 213.301
• Mol file: 96129-76-9.mol

Synonyms:2,6-dimethyl-β-phenethylsulfonamide

Chemical Property of 2,6-dimethyl-β-phenethylsulfonamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2,6-dimethyl-β-phenethylsulfonamide

There total 4 articles about 2,6-dimethyl-β-phenethylsulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

2,6-dimethyl-β-phenethylsulfonyl chloride (88106-96-1) → 2,6-dimethyl-β-phenethylsulfonamide (96129-76-9)

Guidance literature:

With ammonium hydroxide;

DOI:10.1021/jo00212a013

Reference yield:

2,6-dimethyl-β-phenethyl bromide (79927-86-9) → 2,6-dimethyl-β-phenethylsulfonamide (96129-76-9)

Guidance literature:

Multi-step reaction with 4 steps

1: 79.5 percent / Na₂SO₃ / aq. ethanol; H₂O

2: 85 percent / SOCl₂ / benzene; dimethylformamide

3: 87.3 percent / NaN₃ / acetone; H₂O / 24 h / Ambient temperature

4: 1,1,2-trichloro-1,2,2-trifluoro-ethane / 69 h / 210 °C

With thionyl chloride; sodium azide; sodium sulfite; In ethanol; 1,1,2-Trichloro-1,2,2-trifluoroethane; water; N,N-dimethyl-formamide; acetone; benzene;

DOI:10.1021/jo00212a013

Reference yield:

sodium 2,6-dimethyl-β-phenethylsulfonate (96129-75-8) → 2,6-dimethyl-β-phenethylsulfonamide (96129-76-9)

Guidance literature:

Multi-step reaction with 3 steps

1: 85 percent / SOCl₂ / benzene; dimethylformamide

2: 87.3 percent / NaN₃ / acetone; H₂O / 24 h / Ambient temperature

3: 1,1,2-trichloro-1,2,2-trifluoro-ethane / 69 h / 210 °C

With thionyl chloride; sodium azide; In 1,1,2-Trichloro-1,2,2-trifluoroethane; water; N,N-dimethyl-formamide; acetone; benzene;

DOI:10.1021/jo00212a013

upstream raw materials:

2,6-dimethyl-β-phenethylsulfonyl chloride

2,6-dimethyl-β-phenethylsulfonyl azide

2,6-dimethyl-β-phenethyl bromide

sodium 2,6-dimethyl-β-phenethylsulfonate

Refernces