benzyl N-[(3R)-2-oxo-1,3,4,5-tetrahydro-1-benzazepin-3-yl]carbamate

Base Information

• Chemical Name: benzyl N-[(3R)-2-oxo-1,3,4,5-tetrahydro-1-benzazepin-3-yl]carbamate
• CAS No.: 1310816-92-2
• Molecular Formula: C₁₈H₁₈N₂O₃
• Molecular Weight: 310.353
• Mol file: 1310816-92-2.mol

Synonyms:benzyl N-[(3R)-2-oxo-1,3,4,5-tetrahydro-1-benzazepin-3-yl]carbamate

Chemical Property of benzyl N-[(3R)-2-oxo-1,3,4,5-tetrahydro-1-benzazepin-3-yl]carbamate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of benzyl N-[(3R)-2-oxo-1,3,4,5-tetrahydro-1-benzazepin-3-yl]carbamate

There total 3 articles about benzyl N-[(3R)-2-oxo-1,3,4,5-tetrahydro-1-benzazepin-3-yl]carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

(3R)-3-Amino-1,3,4,5-tetrahydro-1-benzazepin-2-one hydrochloride (639821-05-9) + benzyl chloroformate (501-53-1,94274-21-2) → benzyl N-[(3R)-2-oxo-1,3,4,5-tetrahydro-1-benzazepin-3-yl]carbamate (1310816-92-2)

Guidance literature:

With potassium carbonate; In dichloromethane; water; at 20 ℃; for 16h;

Reference yield:

benzyl chloroformate (501-53-1,94274-21-2) + (R)-3-amino-2,3,4,5-tetrahydro-1H-[1]-benzazepin-2-one (137036-55-6) → benzyl N-[(3R)-2-oxo-1,3,4,5-tetrahydro-1-benzazepin-3-yl]carbamate (1310816-92-2)

Guidance literature:

With sodium carbonate; In water; acetonitrile; at 20 ℃; for 4h;

Reference yield:

((R)-2-oxo-2,3,4,5-tetrahydro-1H-benzo[b]azepin-3-yl)carbamic acid tert-butyl ester (145485-03-6) → benzyl N-[(3R)-2-oxo-1,3,4,5-tetrahydro-1-benzazepin-3-yl]carbamate (1310816-92-2)

Guidance literature:

Multi-step reaction with 2 steps

1: hydrogenchloride; water / methanol / 1 h

2: sodium carbonate / water; acetonitrile / 4 h / 20 °C

With hydrogenchloride; water; sodium carbonate; In methanol; water; acetonitrile;

upstream raw materials:

benzyl chloroformate

(R)-3-amino-2,3,4,5-tetrahydro-1H-[1]-benzazepin-2-one

(3R)-3-Amino-1,3,4,5-tetrahydro-1-benzazepin-2-one hydrochloride

((R)-2-oxo-2,3,4,5-tetrahydro-1H-benzo[b]azepin-3-yl)carbamic acid tert-butyl ester

Downstream raw materials:

4-chloro-N-[1-[[(4R)-5,6-dihydro-4H-imidazo[1,2-a][1]benzazepin-4-yl]carbamoyl]cyclopropyl]benzamide hydrochloride

4-chloro-N-[1-[[(4R)-5,6-dihydro-4H-imidazo[1,2-a][1]benzazepin-4-yl]carbamoyl]cyclopropyl]benzamide 4-methylbenzenesulfonic acid salt

benzyl N-((4R)-1-methyl-5,6-dihydro-4H-imidazo[1,2-a][1]benzazepin-4-yl)carbamate

benzyl N-((4S)-1-methyl-5,6-dihydro-4H-imidazo[1,2-a][1]benzazepin-4-yl)carbamate